Cancer is associated with coronavirus disease (COVID-19) severity and mortality: A pooled analysis

Coronavirus disease 2019 (COVID-19) is a rapidly escalating pandemic that has spread to many parts of the world. As such, there is urgent need to identify predictors of clinical severity in COVID-19 patients. This may be useful for early identification of patients who may require life-saving interve...

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Bibliographic Details
Published in:The American journal of emergency medicine 2021-07, Vol.45, p.179-184
Main Authors: Cheruiyot, Isaac, Kipkorir, Vincent, Ngure, Brian, Misiani, Musa, Munguti, Jeremiah
Format: Article
Language:English
Subjects:
Cancer
Comorbidity
Coronaviruses
COVID-19
COVID-19 - epidemiology
Emergency medical care
Global Health
Heterogeneity
Humans
Infectious diseases
Mortality
Neoplasms - epidemiology
Pandemics
Patients
Risk Assessment - methods
Risk Factors
SARS-CoV-2
Severity
Severity of Illness Index
Survival Rate - trends
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Summary:Coronavirus disease 2019 (COVID-19) is a rapidly escalating pandemic that has spread to many parts of the world. As such, there is urgent need to identify predictors of clinical severity in COVID-19 patients. This may be useful for early identification of patients who may require life-saving interventions. In this meta-analysis, we evaluated whether malignancies are associated with a significantly enhanced odds of COVID-19 severity and mortality. A systematic search of literature was conducted between November 1, 2019, to May 26th, 2020 on PubMed and China National Knowledge Infrastructure (CNKI) to identify studies reporting data on cancers in patients with or without severe COVID-19 were included. The primary outcome of interest was the association between malignancies and COVID-19 severity, while the secondary outcome was the association between malignancies and COVID-19 mortality. Data were pooled into a meta-analysis to estimate pooled odds ratio (OR) with 95% confidence interval (95% CI) for either outcome. A total of 20 studies (n = 4549 patients) were included. Overall, malignancies were found to be associated with significantly increased odds of COVID-19 severity (OR = 2.17; 95% CI 1.47–3.196; p 
ISSN:0735-6757
1532-8171
DOI:10.1016/j.ajem.2020.08.025