Investigating disparities: the effect of social environment on pancreatic cancer survival in metastatic patients

Pancreatic adenocarcinoma (PCA) incidence is higher in Black compared to White patients. Beyond race, neighborhood socioeconomic status (nSES) may also inform disparities. However, these effects on metastatic pancreatic adenocarcinoma (mPCA) are not well-studied. The aim of this study was to explore...

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Bibliographic Details
Published in:Journal of gastrointestinal oncology 2020-08, Vol.11 (4), p.633-643
Main Authors: Madnick, David, Handorf, Elizabeth, Ortiz, Angel, Sorice, Kristen, Nagappan, Lavanya, Moccia, Matthew, Cheema, Khadija, Vijayvergia, Namrata, Dotan, Efrat, Lynch, Shannon M
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Language:English
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Summary:Pancreatic adenocarcinoma (PCA) incidence is higher in Black compared to White patients. Beyond race, neighborhood socioeconomic status (nSES) may also inform disparities. However, these effects on metastatic pancreatic adenocarcinoma (mPCA) are not well-studied. The aim of this study was to explore whether nSES influences survival in patients with mPCA. nSES measures were derived from U.S. census data at the census tract (CT) level. We correlated medical records of mPCA patients (diagnosed 2010-2016; n=370) to nSES measures retrospectively via a geocode derived from patient address. Multivariable cox proportional hazards models were used to identify patient-level (age, sex, race, marital status, treatment (radiation/chemo/surgery), PCA family history, stage, Jewish ancestry, tobacco use, BMI, diabetes, and statin use) and nSES measures (deprivation, racial concentration, stability, transportation access, immigration) associated with mPCA survival; P values
ISSN:2078-6891
2219-679X
DOI:10.21037/jgo-20-39