Pan-metastatic cancer analysis of prognostic factors and a prognosis-based metastatic cancer classification system

We aimed to perform a pan-metastatic cancer analysis on survival and prognostic factors and to create a prognosis-based classification system. We selected distant metastasis patients from the Surveillance, Epidemiology, and End Results (SEER) database. The associations between the characteristics of...

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Bibliographic Details
Published in:Aging (Albany, NY.) NY.), 2020-08, Vol.12 (16), p.16046-16061
Main Authors: Zhang, Chao, Xu, Guijun, Xu, Yao, Wu, Haixiao, Guo, Xu, Mao, Min, Baklaushev, Vladimir P, Chekhonin, Vladimir P, Peltzer, Karl, Bai, Ye, Wang, Guowen, Ma, Wenjuan, Wang, Xin
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Clinical Decision-Making
Decision Support Techniques
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Neoplasm Grading
Neoplasm Metastasis
Neoplasm Staging
Neoplasms - classification
Neoplasms - mortality
Neoplasms - pathology
Neoplasms - therapy
Predictive Value of Tests
Research Paper
Risk Assessment
Risk Factors
SEER Program
United States - epidemiology
Young Adult
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Summary:We aimed to perform a pan-metastatic cancer analysis on survival and prognostic factors and to create a prognosis-based classification system. We selected distant metastasis patients from the Surveillance, Epidemiology, and End Results (SEER) database. The associations between the characteristics of the patients at admission and overall survival were determined. A prognosis-based metastatic cancer classification was established based on the identified prognostic factors. The differences in prognosis among these categories were tested. The survival rate and prognostic factors were not consistent across cancers. Three metastatic cancer categories were generated, each with different prognoses. The prognostic differences among the categories were satisfactorily validated. Different metastatic cancer types had homogeneous and heterogeneous survival rates and prognostic factors. A prognosis-based classification system for synchronous distant metastasis cancer patients at admission was created. This classification system reflects the grade of malignancy in metastatic cancers and may guide the prediction of survival and individualized treatment. Moreover, it may have important implications for the management of synchronous metastatic cancers and aid clinicians in properly allocating medical resources to metastatic patients.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.103467