Tumour biomarkers: association with heart failure outcomes

• Published in: Journal of internal medicine 2020-08, Vol.288 (2), p.207-218
• Main Authors: Shi, C., Wal, H. H., Silljé, H. H. W., Dokter, M. M., den Berg, F., Huizinga, L., Vriesema, M., Post, J., Anker, S. D., Cleland, J. G., Ng, L. L., Samani, N. J., Dickstein, K., Zannad, F., Lang, C. C., Haelst, P. L., Gietema, J. A., Metra, M., Ameri, P., Canepa, M., Veldhuisen, D. J., Voors, A. A., Boer, R. A.
• Format: Article
• Language: English
• Subjects: Aged; alpha-Fetoproteins - analysis; Antigens, Neoplasm - blood; Antigens, Tumor-Associated, Carbohydrate - blood; Biomarkers; Biomarkers, Tumor - blood; CA-125 Antigen - blood; Carcinoembryonic Antigen - blood; Cardiology and cardiovascular system; Cardiovascular diseases; Congestive heart failure; Female; Follow-Up Studies; Heart failure; Heart Failure - blood; Heart Failure - mortality; Hemoglobin; Hospitalization; Human health and pathology; Humans; Keratin-19 - blood; Life Sciences; Male; Membrane Proteins - blood; Mortality; Natriuretic Peptide, Brain - blood; natriuretic peptides; neoplasms; Original; Peptide Fragments - blood; Quartiles; Tumors; tumour
• ISSN: 0954-6820; 1365-2796
• DOI: 10.1111/joim.13053

Background There is increasing recognition that heart failure (HF) and cancer are conditions with a number of shared characteristics. Objectives To explore the association between tumour biomarkers and HF outcomes. Methods In 2,079 patients of BIOSTAT‐CHF cohort, we measured six established tumour biomarkers: CA125, CA15‐3, CA19‐9, CEA, CYFRA 21‐1 and AFP. Results During a median follow‐up of 21 months, 555 (27%) patients reached the primary end‐point of all‐cause mortality. CA125, CYFRA 21‐1, CEA and CA19‐9 levels were positively correlated with NT‐proBNP quartiles (all P