Long‐term outcomes of skull base chordoma treated with high‐dose carbon‐ion radiotherapy

Background We evaluated the long‐term efficacy and safety of carbon‐ion radiotherapy (C‐ion RT) for skull base chordoma, a rare neoplasm. Methods Thirty‐four patients with skull base chordoma who were treated with C‐ion RT were prospectively enrolled and analyzed retrospectively. C‐ion RT was delive...

Full description

Saved in:
Bibliographic Details
Published in:Head & neck 2020-09, Vol.42 (9), p.2607-2613
Main Authors: Koto, Masashi, Ikawa, Hiroaki, Kaneko, Takashi, Hagiwara, Yasuhito, Hayashi, Kazuhiko, Tsuji, Hiroshi
Format: Article
Language:English
Subjects:
carbon‐ion
Head and neck
long‐term outcome
Mucosa
Optic nerve
Original
Radiation therapy
radiotherapy
rare tumor
Skull
skull base chordoma
Ulcers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background We evaluated the long‐term efficacy and safety of carbon‐ion radiotherapy (C‐ion RT) for skull base chordoma, a rare neoplasm. Methods Thirty‐four patients with skull base chordoma who were treated with C‐ion RT were prospectively enrolled and analyzed retrospectively. C‐ion RT was delivered with 60.8 Gy (relative biological effectiveness [RBE]) in 16 fractions at four fractions per week. Results The median follow‐up period was 108 months. The 5‐ and 9‐year local control rates were 76.9% and 69.2%, respectively. The 5‐ and 9‐year overall survival rates were 93.5% and 77.4%, respectively. Regarding grade 3 or more severe late reactions, one patient developed a grade 3 mucosal ulcer, two developed grade 4 ipsilateral optic nerve injuries, and one developed a grade 5 mucosal ulcer at 9 years and 3 months after C‐ion RT. Conclusion C‐ion RT with 60.8 Gy (RBE)/16 fractions is a promising treatment option for inoperable skull base chordoma.
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26307