Anxiety risk SNPs on chromosome 2 modulate arousal in children in a fear generalization paradigm

Alterations in fear learning/generalization are considered to be relevant mechanisms engendering the development of anxiety disorders being the most prevalent mental disorders. Although anxiety disorders almost exclusively have their first onset in childhood and adolescence, etiological research foc...

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Bibliographic Details
Published in:European child & adolescent psychiatry 2020-09, Vol.29 (9), p.1301-1310
Main Authors: Reinhard, Julia, Drepper, Carsten, Weber, Heike, Schiele, Miriam A., Kneer, Katharina, Mittermeier, Anna, Frey, Lillien, Reif, Andreas, Pauli, Paul, Domschke, Katharina, Deckert, Jürgen, Romanos, Marcel
Format: Article
Language:English
Subjects:
Age of onset
Anxiety
Anxiety disorders
Anxiety Disorders - psychology
Arousal
Child
Child & adolescent psychiatry
Child and Adolescent Psychiatry
Children
Chromosome 2
Chromosomes
Chromosomes, Human, Pair 2 - genetics
Conditioning
Fear & phobias
Fear - psychology
Fear conditioning
Female
Generalization, Psychological - physiology
Genome-wide association studies
Genomes
Genomics
Genotyping Techniques
Humans
Male
Medicine
Medicine & Public Health
Mental disorders
Original Contribution
Paradigms
Personality traits
Polymorphism, Single Nucleotide - genetics
Psychiatry
Single-nucleotide polymorphism
Susceptibility
Systematic review
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Summary:Alterations in fear learning/generalization are considered to be relevant mechanisms engendering the development of anxiety disorders being the most prevalent mental disorders. Although anxiety disorders almost exclusively have their first onset in childhood and adolescence, etiological research focuses on adult individuals. In this study, we evaluated findings of a recent meta-analysis of genome-wide association studies in adult anxiety disorders with significant associations of four single nucleotide polymorphisms (SNPs) in a large cohort of 347 healthy children (8–12 years) characterized for dimensional anxiety. We investigated the modulation of anxiety parameters by these SNPs in a discriminative fear conditioning and generalization paradigm in the to-date largest sample of children. Results extended findings of the meta-analysis showing a genomic locus on 2p21 to modulate anxious personality traits and arousal ratings. These SNPs might, thus, serve as susceptibility markers for a shared risk across pathological anxiety, presumably mediated by alterations in arousal.
ISSN:1018-8827
1435-165X
DOI:10.1007/s00787-019-01458-7