Circulating miRNA-23b and miRNA-143 Are Potential Biomarkers for In-Stent Restenosis

In-stent restenosis (ISR) is one of the main complications in patients undergoing percutaneous coronary angioplasty, and microRNAs participate in the contractile-to-synthetic phenotypic switch of vascular smooth muscle cells, a hallmark of restenosis development. MicroRNAs (miRNAs) can be released i...

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Bibliographic Details
Published in:BioMed research international 2020, Vol.2020 (2020), p.1-6
Main Authors: Zambrano, Tomás, Lanas, Fernando, Salazar, Luis A., Pérez, Luis, Bobadilla, Braulio, Bustos, Luis, Ruedlinger, Jenny, Rebolledo, Camilo, Herrera, Jesús, Rojas, Gabriel, Saavedra, Nicolás, Saavedra, Kathleen
Format: Article
Language:English
Subjects:
Aged
Angiography
Angioplasty
Angioplasty, Balloon, Coronary - methods
Area Under Curve
Biomarkers
Biomarkers - blood
Blood pressure
Body mass index
Cardiovascular disease
Circulating MicroRNA - blood
Circulating MicroRNA - metabolism
Complications
Constriction, Pathologic - blood
Constriction, Pathologic - metabolism
Coronary Angiography - methods
Coronary artery
Coronary artery disease
Coronary Restenosis - blood
Coronary Restenosis - metabolism
Coronary vessels
Diabetes
Diagnostic systems
Female
Gene expression
Heart diseases
Heart rate
Humans
Hyperplasia
Hypertension
Implants
Logistic Models
Male
Medical imaging
MicroRNAs
MicroRNAs - blood
Middle Aged
miRNA
Muscle contraction
Muscles
Myocytes, Smooth Muscle - metabolism
Plasma
Plasma levels
Restenosis
ROC Curve
Smooth muscle
Statistical analysis
Stents
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Summary:In-stent restenosis (ISR) is one of the main complications in patients undergoing percutaneous coronary angioplasty, and microRNAs participate in the contractile-to-synthetic phenotypic switch of vascular smooth muscle cells, a hallmark of restenosis development. MicroRNAs (miRNAs) can be released into circulation from injured tissues, enticing a potential role as noninvasive biomarkers. We aimed to evaluate circulating levels of miRNA-23b, miRNA-143, and miRNA-145 as diagnostic markers of ISR. 142 patients with coronary artery disease undergoing successful angioplasty and a follow-up angiography were included. Subjects were classified according to the degree of obstruction at the angioplasty site into cases (≥50%) or controls (
ISSN:2314-6133
2314-6141
DOI:10.1155/2020/2509039