Analysis of sputum/tracheal aspirate and nasopharyngeal samples for SARS-CoV-2 detection by laboratory-developed test and Panther Fusion system

In this study, 127 sputum/tracheal aspirate specimens were evaluated by a laboratory-developed real-time RT-PCR method and Fusion SARS-CoV-2 assay. These specimens were collected from the patients who have nasopharyngeal swab (NPS) samples being used for SARS-CoV-2 detection previously or simultaneo...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2021-01, Vol.99 (1), p.115228-115228, Article 115228
Main Authors: Thwe, Phyu M., Ren, Ping
Format: Article
Language:English
Subjects:
COVID-19
COVID-19 - diagnosis
COVID-19 Nucleic Acid Testing - methods
Humans
Limit of Detection
Lower respiratory tract
Nasopharyngeal swab sample
Nasopharynx - virology
SARS-CoV-2
SARS-CoV-2 - genetics
SARS-CoV-2 - isolation & purification
Sputum
Sputum - virology
Tracheal aspirate
Virology
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Summary:In this study, 127 sputum/tracheal aspirate specimens were evaluated by a laboratory-developed real-time RT-PCR method and Fusion SARS-CoV-2 assay. These specimens were collected from the patients who have nasopharyngeal swab (NPS) samples being used for SARS-CoV-2 detection previously or simultaneously. The overall agreement was 96% between the lower respiratory tract (LRT) and NPS samples, suggesting that LRT specimens could be an option for patients who develop a productive cough or those receiving invasive mechanical ventilation.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2020.115228