Mass Spectrometry for COVID-19

In the United States, response to the COVID-19 coronavirus pandemic has been hampered by inadequate testing resources for the causative virus SARS-CoV-2. In the early part of the pandemic, United States laboratories were initially heavily regulated and slow to provide testing. As the pandemic has pr...

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Bibliographic Details
Published in:Clinical Chemistry 2020-11, Vol.66 (11), p.1367-1368
Main Authors: SoRelle, Jeffrey A, Patel, Khushbu, Filkins, Laura, Park, Jason Y
Format: Article
Language:English
Subjects:
Analysis
Betacoronavirus - genetics
Clinical Laboratory Techniques
Contact Tracing
Control
Coronavirus Infections - diagnosis
Coronaviruses
COVID-19
COVID-19 Testing
Epidemics
Humans
Laboratories
Limit of Detection
Mass spectrometry
Mass spectroscopy
Nasal Mucosa - virology
Pandemics
Pneumonia, Viral - diagnosis
Proof of Concept Study
Reverse Transcriptase Polymerase Chain Reaction
SARS-CoV-2
Smartphone
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
United States
Viral infections
Viral Load
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Summary:In the United States, response to the COVID-19 coronavirus pandemic has been hampered by inadequate testing resources for the causative virus SARS-CoV-2. In the early part of the pandemic, United States laboratories were initially heavily regulated and slow to provide testing. As the pandemic has progressed, the supply chain for instruments and reagents has been inconsistent and has revealed weaknesses in traditional sophisticated infectious disease testing. Testing capabilities of clinical laboratories could be substantially improved by assays that are more simplified and do not require multiple consumable reagents for extraction, purification, amplification and detection. One such technology with the potential to require minimal reagents is matrix-assisted laser desorption/ionization combined with mass spectrometry (MALDI-MS). Recently, Nachtigall and colleagues reported the development of a MALDI-MS method for the diagnosis of SARS-CoV-2 infection (1).
ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/hvaa222