Feasibility and Safety of Outpatient Parenteral Antimicrobial Therapy in Conjunction With Addiction Treatment for People Who Inject Drugs

Abstract Background Research is limited on combining outpatient parenteral antimicrobial therapy (OPAT) with addiction treatment for people who inject drugs (PWID) with serious infections. Methods This is a retrospective study of PWID (n = 68) requiring intravenous antibiotics evaluated for suitabil...

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Bibliographic Details
Published in:The Journal of infectious diseases 2020-09, Vol.222 (Supplement_5), p.S494-S498
Main Authors: Price, Christin N, Solomon, Daniel A, Johnson, Jennifer A, Montgomery, Mary W, Martin, Bianca, Suzuki, Joji
Format: Article
Language:English
Subjects:
Addictions
Administration, Intravenous - adverse effects
Administration, Intravenous - instrumentation
Adult
Ambulatory Care - methods
Ambulatory Care - statistics & numerical data
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Antibiotics
Antimicrobial agents
Bacteremia
Bacteremia - drug therapy
Bacteremia - microbiology
Bone Diseases, Infectious - drug therapy
Bone Diseases, Infectious - microbiology
Catheters
Central Venous Catheters - adverse effects
Drug addiction
Endocarditis
Endocarditis, Bacterial - drug therapy
Endocarditis, Bacterial - microbiology
Feasibility Studies
Female
Humans
Infections
Intravenous administration
Male
Methadone
Middle Aged
Narcotics
Overdose
Patient Readmission - statistics & numerical data
Retrospective Studies
Substance abuse treatment
Substance Abuse, Intravenous - complications
Substance Abuse, Intravenous - therapy
Supplement
Treatment Outcome
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Summary:Abstract Background Research is limited on combining outpatient parenteral antimicrobial therapy (OPAT) with addiction treatment for people who inject drugs (PWID) with serious infections. Methods This is a retrospective study of PWID (n = 68) requiring intravenous antibiotics evaluated for suitability for our OPAT program with concurrent addiction treatment. Results Most common infections were bacteremia and/or endocarditis (73.5%), bone and/or joint infections (32.4%), and epidural abscess (22.1%). Of the 20 patients (29.4%) who qualified, 100.0% completed the course of antibiotics, 30.0% experienced a 30-day readmission, and 15.0% relapsed. No overdoses, deaths, or peripherally inserted central catheter-line complications were reported. Conclusions Outpatient parenteral antimicrobial therapy with addiction treatment may be feasible and safe for PWID with serious infections.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiaa025