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Provisional case definitions for COVID-19-associated neurological disease – Authors' reply

Additionally, the study by Kong and colleagues3 cited by Li and colleagues' Correspondence did not report co-infection, but rather early cases of COVID-19 in Wuhan, China, that were detected through the national influenza surveillance programme; existing influenza surveillance networks have bee...

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Published in:Lancet neurology 2020-11, Vol.19 (11), p.891-892
Main Authors: Solomon, Tom, Benjamin, Laura, Singh, Bhagteshwar, Lant, Suzannah, Ellul, Mark A
Format: Article
Language:English
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Summary:Additionally, the study by Kong and colleagues3 cited by Li and colleagues' Correspondence did not report co-infection, but rather early cases of COVID-19 in Wuhan, China, that were detected through the national influenza surveillance programme; existing influenza surveillance networks have been used for sentinel testing and to look for potential signs of community transmission worldwide, as supported by the WHO Global Influenza Surveillance and Response System. Furthermore, influenza-like illness is a syndromic definition and does not imply influenza to be the causative illness; its description aligns closely with the “acute respiratory infection” definition used to prompt testing for COVID-19 in earlier WHO and national guidelines.4 Our group has shown previously that, in patients with new neurological disease and evidence of more than one infection, there are additional challenges in thinking about causality, particularly when the results are from specimens collected outside the CNS.5,6 TS was an advisor for the GlaxoSmithKline ebola vaccine programme, chaired the Siemens diagnostics clinical advisory board and healthineers clinical advisory board, and also has a pending patent test for bacterial meningitis based on a blood test (GB 1606537.7; April 14, 2016). BS reports non-financial support from UK National Institute for Health Research through its Global Health Research Group on Brain Infections, outside the submitted work.
ISSN:1474-4422
1474-4465
DOI:10.1016/S1474-4422(20)30362-8