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Growth hormone alleviates oxidative stress and improves oocyte quality in Chinese women with polycystic ovary syndrome: a randomized controlled trial
Oxidative stress (OS) is associated with poor oocyte quality and in vitro fertilization and embryo transfer (IVF-ET) outcomes for patients with polycystic ovary syndrome (PCOS). Growth hormone (GH) can function to reduce OS in some types of cells. Therefore, this prospective randomized study investi...
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| Published in: | Scientific reports 2020-10, Vol.10 (1), p.18769, Article 18769 |
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| creator | Gong, Yan Luo, Shan Fan, Ping Jin, Song Zhu, Huili Deng, Tang Quan, Yi Huang, Wei |
| description | Oxidative stress (OS) is associated with poor oocyte quality and in vitro fertilization and embryo transfer (IVF-ET) outcomes for patients with polycystic ovary syndrome (PCOS). Growth hormone (GH) can function to reduce OS in some types of cells. Therefore, this prospective randomized study investigated whether GH can significantly improve OS and oocyte quality in women with PCOS. This study enrolled 109 and 50 patients with and without PCOS (controls), respectively. The patients with PCOS were randomly assigned to receive treatment with GH (PCOS-T) or not (PCOS-C). The primary outcome included markers of OS in serum and FF, and secondary outcomes were mitochondrial function in granulosa cells (GCs) and IVF-ET outcomes. The PCOS groups showed higher basal serum total oxidant status (TOS) and OS index (OSI) levels. The follicle fluid (FF) TOS and OSI and GC apoptosis rate were significantly higher, whereas the GC mitochondrial membrane potential (MMP) was significantly lower in the PCOS-C group than in the PCOS-T and non-PCOS control groups (
P
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| doi_str_mv | 10.1038/s41598-020-75107-4 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7599233</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2471529197</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-7ea389dc08665cdd9bf016dfaddbf4f96f719dc2c864628e0858bc8530739be13</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhSMEolXpC7BAllgH_JfYZoGERlCQKrGBteXYNx1XiT21PZmG9-B9cZlSygZvbOmc-90jn6Z5SfAbgpl8mznplGwxxa3oCBYtf9KcUsy7ljJKnz56nzTnOV_jejqqOFHPmxPGCBVKkNPm50WKh7JF25jmGACZaYLFmwIZxVvvTPELoFwS5IxMcMjPuxSXOzXatQC62ZvJlxX5gDZbHyADOsQZAjr4St3FabVrLt6iuJi0orwGl6r-DhmUKi_O_gc4ZGMoKdbVDpXkzfSieTaaKcP5_X3WfP_08dvmc3v59eLL5sNla7ngpRVgmFTOYtn3nXVODSMmvRuNc8PIR9WPglSZWtnznkrAspODlR3DgqkBCDtr3h-5u_0wg7NQY5hJ75Kfa1odjdf_KsFv9VVctOiUooxVwOt7QIo3e8hFX8d9CjWzplyQ-uFEieqiR5dNMecE48MGgvVdm_rYpq5t6t9tal6HXj3O9jDyp7tqYEdDrlK4gvR393-wvwDZebB7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471529197</pqid></control><display><type>article</type><title>Growth hormone alleviates oxidative stress and improves oocyte quality in Chinese women with polycystic ovary syndrome: a randomized controlled trial</title><source>Full-Text Journals in Chemistry (Open access)</source><source>Publicly Available Content (ProQuest)</source><source>PubMed Central</source><source>Springer Nature - nature.com Journals - Fully Open Access</source><creator>Gong, Yan ; Luo, Shan ; Fan, Ping ; Jin, Song ; Zhu, Huili ; Deng, Tang ; Quan, Yi ; Huang, Wei</creator><creatorcontrib>Gong, Yan ; Luo, Shan ; Fan, Ping ; Jin, Song ; Zhu, Huili ; Deng, Tang ; Quan, Yi ; Huang, Wei</creatorcontrib><description>Oxidative stress (OS) is associated with poor oocyte quality and in vitro fertilization and embryo transfer (IVF-ET) outcomes for patients with polycystic ovary syndrome (PCOS). Growth hormone (GH) can function to reduce OS in some types of cells. Therefore, this prospective randomized study investigated whether GH can significantly improve OS and oocyte quality in women with PCOS. This study enrolled 109 and 50 patients with and without PCOS (controls), respectively. The patients with PCOS were randomly assigned to receive treatment with GH (PCOS-T) or not (PCOS-C). The primary outcome included markers of OS in serum and FF, and secondary outcomes were mitochondrial function in granulosa cells (GCs) and IVF-ET outcomes. The PCOS groups showed higher basal serum total oxidant status (TOS) and OS index (OSI) levels. The follicle fluid (FF) TOS and OSI and GC apoptosis rate were significantly higher, whereas the GC mitochondrial membrane potential (MMP) was significantly lower in the PCOS-C group than in the PCOS-T and non-PCOS control groups (
P
< 0.05). Significantly more oocytes were fertilised and cleavage stage embryos were produced in the PCOS-T group than in the PCOS-C group (
P
< 0.05). GH also improved the rates of implantation and clinical pregnancy, but not significantly (
P
> 0.05). This study showed that GH alleviated the TOS and OSI level in FF and improved GC mitochondrial dysfunction and oocyte quality in patients with PCOS.
Clinical Trial Registration Number:
This project was prospectively registered on the Chinese Clinical Trial Registry on October 20, 2018. (ChiCTR1800019437) (
https://www.chictr.org.cn/edit.aspx?pid=28663&htm=4
).</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-75107-4</identifier><identifier>PMID: 33127971</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/154 ; 631/80 ; 692/163 ; 692/308 ; 692/53 ; 692/699 ; Apoptosis ; China ; Clinical trials ; Embryo transfer ; Embryos ; Female ; Granulosa cells ; Growth Hormone - pharmacology ; Growth Hormone - therapeutic use ; Growth hormones ; Humanities and Social Sciences ; Humans ; Implantation ; In vitro fertilization ; Membrane potential ; Mitochondria ; multidisciplinary ; Oocytes ; Oocytes - drug effects ; Ovaries ; Oxidants ; Oxidative stress ; Oxidative Stress - drug effects ; Oxidizing agents ; Patients ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - drug therapy ; Polycystic Ovary Syndrome - physiopathology ; Prospective Studies ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2020-10, Vol.10 (1), p.18769, Article 18769</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-7ea389dc08665cdd9bf016dfaddbf4f96f719dc2c864628e0858bc8530739be13</citedby><cites>FETCH-LOGICAL-c474t-7ea389dc08665cdd9bf016dfaddbf4f96f719dc2c864628e0858bc8530739be13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2471529197/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2471529197?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,25734,27905,27906,36993,44571,53772,53774,74875</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33127971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gong, Yan</creatorcontrib><creatorcontrib>Luo, Shan</creatorcontrib><creatorcontrib>Fan, Ping</creatorcontrib><creatorcontrib>Jin, Song</creatorcontrib><creatorcontrib>Zhu, Huili</creatorcontrib><creatorcontrib>Deng, Tang</creatorcontrib><creatorcontrib>Quan, Yi</creatorcontrib><creatorcontrib>Huang, Wei</creatorcontrib><title>Growth hormone alleviates oxidative stress and improves oocyte quality in Chinese women with polycystic ovary syndrome: a randomized controlled trial</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Oxidative stress (OS) is associated with poor oocyte quality and in vitro fertilization and embryo transfer (IVF-ET) outcomes for patients with polycystic ovary syndrome (PCOS). Growth hormone (GH) can function to reduce OS in some types of cells. Therefore, this prospective randomized study investigated whether GH can significantly improve OS and oocyte quality in women with PCOS. This study enrolled 109 and 50 patients with and without PCOS (controls), respectively. The patients with PCOS were randomly assigned to receive treatment with GH (PCOS-T) or not (PCOS-C). The primary outcome included markers of OS in serum and FF, and secondary outcomes were mitochondrial function in granulosa cells (GCs) and IVF-ET outcomes. The PCOS groups showed higher basal serum total oxidant status (TOS) and OS index (OSI) levels. The follicle fluid (FF) TOS and OSI and GC apoptosis rate were significantly higher, whereas the GC mitochondrial membrane potential (MMP) was significantly lower in the PCOS-C group than in the PCOS-T and non-PCOS control groups (
P
< 0.05). Significantly more oocytes were fertilised and cleavage stage embryos were produced in the PCOS-T group than in the PCOS-C group (
P
< 0.05). GH also improved the rates of implantation and clinical pregnancy, but not significantly (
P
> 0.05). This study showed that GH alleviated the TOS and OSI level in FF and improved GC mitochondrial dysfunction and oocyte quality in patients with PCOS.
Clinical Trial Registration Number:
This project was prospectively registered on the Chinese Clinical Trial Registry on October 20, 2018. (ChiCTR1800019437) (
https://www.chictr.org.cn/edit.aspx?pid=28663&htm=4
).</description><subject>631/154</subject><subject>631/80</subject><subject>692/163</subject><subject>692/308</subject><subject>692/53</subject><subject>692/699</subject><subject>Apoptosis</subject><subject>China</subject><subject>Clinical trials</subject><subject>Embryo transfer</subject><subject>Embryos</subject><subject>Female</subject><subject>Granulosa cells</subject><subject>Growth Hormone - pharmacology</subject><subject>Growth Hormone - therapeutic use</subject><subject>Growth hormones</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Implantation</subject><subject>In vitro fertilization</subject><subject>Membrane potential</subject><subject>Mitochondria</subject><subject>multidisciplinary</subject><subject>Oocytes</subject><subject>Oocytes - drug effects</subject><subject>Ovaries</subject><subject>Oxidants</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidizing agents</subject><subject>Patients</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - 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Growth hormone (GH) can function to reduce OS in some types of cells. Therefore, this prospective randomized study investigated whether GH can significantly improve OS and oocyte quality in women with PCOS. This study enrolled 109 and 50 patients with and without PCOS (controls), respectively. The patients with PCOS were randomly assigned to receive treatment with GH (PCOS-T) or not (PCOS-C). The primary outcome included markers of OS in serum and FF, and secondary outcomes were mitochondrial function in granulosa cells (GCs) and IVF-ET outcomes. The PCOS groups showed higher basal serum total oxidant status (TOS) and OS index (OSI) levels. The follicle fluid (FF) TOS and OSI and GC apoptosis rate were significantly higher, whereas the GC mitochondrial membrane potential (MMP) was significantly lower in the PCOS-C group than in the PCOS-T and non-PCOS control groups (
P
< 0.05). Significantly more oocytes were fertilised and cleavage stage embryos were produced in the PCOS-T group than in the PCOS-C group (
P
< 0.05). GH also improved the rates of implantation and clinical pregnancy, but not significantly (
P
> 0.05). This study showed that GH alleviated the TOS and OSI level in FF and improved GC mitochondrial dysfunction and oocyte quality in patients with PCOS.
Clinical Trial Registration Number:
This project was prospectively registered on the Chinese Clinical Trial Registry on October 20, 2018. (ChiCTR1800019437) (
https://www.chictr.org.cn/edit.aspx?pid=28663&htm=4
).</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33127971</pmid><doi>10.1038/s41598-020-75107-4</doi><oa>free_for_read</oa></addata></record> |
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| source | Full-Text Journals in Chemistry (Open access); Publicly Available Content (ProQuest); PubMed Central; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 631/154 631/80 692/163 692/308 692/53 692/699 Apoptosis China Clinical trials Embryo transfer Embryos Female Granulosa cells Growth Hormone - pharmacology Growth Hormone - therapeutic use Growth hormones Humanities and Social Sciences Humans Implantation In vitro fertilization Membrane potential Mitochondria multidisciplinary Oocytes Oocytes - drug effects Ovaries Oxidants Oxidative stress Oxidative Stress - drug effects Oxidizing agents Patients Polycystic ovary syndrome Polycystic Ovary Syndrome - drug therapy Polycystic Ovary Syndrome - physiopathology Prospective Studies Science Science (multidisciplinary) |
| title | Growth hormone alleviates oxidative stress and improves oocyte quality in Chinese women with polycystic ovary syndrome: a randomized controlled trial |
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