Viraemia before, during and after pregnancy in HIV‐infected women on antiretroviral therapy in rural KwaZulu‐Natal, South Africa, 2010–2015

Objectives Pregnancy and post‐partum viral load suppression is critical to prevent mother‐to‐child HIV transmission and ensure maternal health. We measured viraemia risk before, during and after pregnancy in HIV‐infected women. Methods Between 2010 and 2015, 1425 HIV‐infected pregnant women on lifel...

Full description

Saved in:
Bibliographic Details
Published in:Tropical medicine & international health 2018-01, Vol.23 (1), p.79-91
Main Authors: Chetty, Terusha, Newell, Marie‐Louise, Thorne, Claire, Coutsoudis, Anna
Format: Article
Language:English
Subjects:
adolescent
adolescents
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Disease transmission
Drug therapy
Duration
grossesse
Health risks
HIV
HIV infection
Human immunodeficiency virus
infection VIH
Maternal & child health
Multilevel
post‐partum
Pregnancy
Ratios
Risk
Risk factors
Rural areas
Tenofovir
Therapy
viraemia
Viremia
virémie
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives Pregnancy and post‐partum viral load suppression is critical to prevent mother‐to‐child HIV transmission and ensure maternal health. We measured viraemia risk before, during and after pregnancy in HIV‐infected women. Methods Between 2010 and 2015, 1425 HIV‐infected pregnant women on lifelong antiretroviral therapy (ART) for at least six months pre‐pregnancy were enrolled in a cohort study in rural KwaZulu‐Natal, South Africa. Odds ratios were estimated in multilevel logistic regression, with pregnancy period time‐varying. Results Over half of 1425 women received tenofovir‐based regimens (n = 791). Median pre‐pregnancy ART duration was 2.1 years. Of 988 women (69.3%) with pre‐pregnancy viral loads, 82.0%, 6.8% and 11.2% had VL
ISSN:1360-2276
1365-3156
DOI:10.1111/tmi.13001