In vivo and in vitro inflammatory responses to fine particulate matter (PM2.5) from China and California

[Display omitted] •Time lag effects following an acute exposure to three PM samples were evaluated.•All three PM samples induced acute, but transient inflammation in the lungs of mice.•All three PM samples induced AhR and inflammatory gene expressions in human U937 cells.•Time lag effects for PM sam...

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Bibliographic Details
Published in:	Toxicology letters 2020-08, Vol.328, p.52-60
Main Authors:	Yuan, Wanjun, Fulgar, Ciara C., Sun, Xiaolin, Vogel, Christoph F.A., Wu, Ching-Wen, Zhang, Qi, Bein, Keith J., Young, Dominique E., Li, Wei, Wei, Haiying, Pinkerton, Kent E.
Format:	Article
Language:	English
Subjects:	Air Pollutants - toxicity Air pollution Animals Aryl hydrocarbon receptor Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology California China Cytokines - metabolism Environmental Monitoring - methods Hep G2 Cells Human macrophages Humans Inhalation Exposure - adverse effects Inhalation Exposure - analysis Lung - drug effects Lung - immunology Lung - pathology Male Mice Mice, Inbred BALB C Particle Size Particulate Matter - toxicity PM2.5 Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Time-lag study Transcription, Genetic - drug effects U937 Cells
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