Graph-based semi-supervised learning with genomic data integration using condition-responsive genes applied to phenotype classification

• Published in: Journal of the American Medical Informatics Association : JAMIA 2018-01, Vol.25 (1), p.99-108
• Main Authors: Doostparast Torshizi, Abolfazl, Petzold, Linda R
• Format: Article
• Language: English
• Subjects: Algorithms; Computational Biology; DNA Methylation; Editor's Choice; Female; Gene Expression; Genomics; Humans; Metabolic Networks and Pathways; Ovarian Neoplasms - genetics; Phenotype; Research and Applications; Supervised Machine Learning
• ISSN: 1067-5027; 1527-974X; 1527-974X
• DOI: 10.1093/jamia/ocx032

Abstract Objective Data integration methods that combine data from different molecular levels such as genome, epigenome, transcriptome, etc., have received a great deal of interest in the past few years. It has been demonstrated that the synergistic effects of different biological data types can boost learning capabilities and lead to a better understanding of the underlying interactions among molecular levels. Methods In this paper we present a graph-based semi-supervised classification algorithm that incorporates latent biological knowledge in the form of biological pathways with gene expression and DNA methylation data. The process of graph construction from biological pathways is based on detecting condition-responsive genes, where 3 sets of genes are finally extracted: all condition responsive genes, high-frequency condition-responsive genes, and P-value–filtered genes. Results The proposed approach is applied to ovarian cancer data downloaded from the Human Genome Atlas. Extensive numerical experiments demonstrate superior performance of the proposed approach compared to other state-of-the-art algorithms, including the latest graph-based classification techniques. Conclusions Simulation results demonstrate that integrating various data types enhances classification performance and leads to a better understanding of interrelations between diverse omics data types. The proposed approach outperforms many of the state-of-the-art data integration algorithms.