Repositioned Drugs for Chagas Disease Unveiled via Structure-Based Drug Repositioning

Chagas disease, caused by the parasite Trypanosoma cruzi, affects millions of people in South America. The current treatments are limited, have severe side effects, and are only partially effective. Drug repositioning, defined as finding new indications for already approved drugs, has the potential...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2020-11, Vol.21 (22), p.8809
Main Authors: Adasme, Melissa F., Bolz, Sarah Naomi, Adelmann, Lauren, Salentin, Sebastian, Haupt, V. Joachim, Moreno-Rodríguez, Adriana, Nogueda-Torres, Benjamín, Castillo-Campos, Verónica, Yepez-Mulia, Lilián, De Fuentes-Vicente, José A., Rivera, Gildardo, Schroeder, Michael
Format: Article
Language:English
Subjects:
Animals
Antibiotics
Binding sites
Cell Line
Chagas disease
Chagas Disease - drug therapy
Ciprofloxacin - chemistry
Ciprofloxacin - pharmacology
Dehydrogenases
Dihydrofolate reductase
Drug Repositioning
Drugs
Folic Acid - chemistry
Folic Acid - pharmacology
Free radicals
Infections
Ligands
Mice
Naproxen - chemistry
Naproxen - pharmacology
Parasites
Pharmaceutical industry
Proteins
Protozoa
Structure-Activity Relationship
Tropical diseases
Trypanocidal Agents - chemistry
Trypanocidal Agents - pharmacology
Trypanosoma cruzi - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!