Women who experience a myocardial infarction at a young age have worse outcomes compared with men: the Mass General Brigham YOUNG-MI registry

• Published in: European heart journal 2020-11, Vol.41 (42), p.4127-4137
• Main Authors: DeFilippis, Ersilia M, Collins, Bradley L, Singh, Avinainder, Biery, David W, Fatima, Amber, Qamar, Arman, Berman, Adam N, Gupta, Ankur, Cawley, Mary, Wood, Malissa J, Klein, Josh, Hainer, Jon, Gulati, Martha, Taqueti, Viviany R, Di Carli, Marcelo F, Nasir, Khurram, Bhatt, Deepak L, Blankstein, Ron
• Format: Article
• Language: English
• Subjects: Adult; Clinical Research; Coronary Angiography; Coronary Artery Disease; Female; Humans; Male; Middle Aged; Myocardial Infarction - epidemiology; Myocardial Infarction - therapy; Registries; Risk Factors; Sex Factors; Treatment Outcome
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/eurheartj/ehaa662

Abstract Aims There are sex differences in presentation, treatment, and outcomes of myocardial infarction (MI) but less is known about these differences in a younger patient population. The objective of this study was to investigate sex differences among individuals who experience their first MI at a young age. Methods and results Consecutive patients presenting to two large academic medical centres with a Type 1 MI at ≤50 years of age between 2000 and 2016 were included. Cause of death was adjudicated using electronic health records and death certificates. In total, 2097 individuals (404 female, 19%) had an MI (mean age 44 ± 5.1 years, 73% white). Risk factor profiles were similar between men and women, although women were more likely to have diabetes (23.7% vs. 18.9%, P = 0.028). Women were less likely to undergo invasive coronary angiography (93.5% vs. 96.7%, P = 0.003) and coronary revascularization (82.1% vs. 92.6%, P