Failure of Proton Pump Inhibitors to Treat GERD in Neonates and Infants: A Question of Drug, Diagnosis, or Design

“The only time you don't fail is the last time you try anything—and it works.”        –William Strong Distressful symptoms associated with gastroesophageal reflux constitute a clinical description of gastroesophageal reflux disease, a pathologic condition commonly treated with proton pump inhib...

Full description

Saved in:
Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2012-09, Vol.92 (3), p.388-392
Main Authors: Shakhnovich, V, Ward, R M, Kearns, G L
Format: Article
Language:English
Subjects:
Biological and medical sciences
Gastroesophageal Reflux - drug therapy
Gastroesophageal Reflux - epidemiology
Humans
Infant
Infant, Newborn
Infant, Newborn, Diseases - drug therapy
Medical sciences
Off-Label Use - statistics & numerical data
Pharmacology. Drug treatments
Practice Patterns, Physicians
Proton Pump Inhibitors - adverse effects
Proton Pump Inhibitors - therapeutic use
Treatment Failure
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:“The only time you don't fail is the last time you try anything—and it works.”        –William Strong Distressful symptoms associated with gastroesophageal reflux constitute a clinical description of gastroesophageal reflux disease, a pathologic condition commonly treated with proton pump inhibitors (PPIs). Despite their pervasive use in neonates and infants, PPIs have not been approved for gastroesophageal reflux disease treatment in this population. This creates a therapeutic conundrum: namely, whether to institute PPI treatment based on knowledge and experience or to withhold it consequent to absence of labeling for young infants. Clinical Pharmacology & Therapeutics (2012); 92 3, 388–392. doi:10.1038/clpt.2012.86
ISSN:0009-9236
1532-6535
DOI:10.1038/clpt.2012.86