Functional parcellation of the right cerebellar lobule VI in children with normal or impaired reading

• Published in: Neuropsychologia 2020-11, Vol.148, p.107630-107630, Article 107630
• Main Authors: Li, Hehui, Booth, James R., Feng, Xiaoxia, Wei, Na, Zhang, Manli, Zhang, Jia, Zhong, Hejing, Lu, Chunming, Liu, Li, Ding, Guosheng, Meng, Xiangzhi
• Format: Article
• Language: English
• Subjects: Functional connectivity; Phonological; Reading impairment; Right cerebellar lobule VI; The cerebellum
• ISSN: 0028-3932; 1873-3514
• DOI: 10.1016/j.neuropsychologia.2020.107630

Neuroimaging studies have reported that the right cerebellar lobule VI is engaged in reading, but its role is unclear. The goal of our study was to identify functionally-dissociable subregions in the right lobule VI and how these subregions contribute to reading in children with normal or impaired reading. In Experiment I, typically developing children performed an orthographic task and a phonological task during functional magnetic resonance imaging (fMRI). We classified the voxels in the right lobule VI into seven zones based on the patterns of functional connectivity with the cerebrum across both tasks. In Experiment II, we compared the brain activation and cerebro-cerebellar connectivities of each subregion between children readers with different reading levels. We did not find significant group differences in cerebellar activation. However, we found that impaired readers had considerably higher functional connectivity between R1 and the right angular gyrus and the right precuneus compared to the control group in the phonological task. These findings show that the right cerebellar lobule VI is functionally parceled and its subregions might be differentially connected with the cerebrum between children with normal reading abilities and those with impaired reading. •We investigated functional parcellation of the right cerebellar lobule VI in reading.•Seven subregions were identified based on the FC patterns during tasks.•The subregions suggest to be implicated in domain-general and language processing.•Impaired reading was associated with abnormality of the sensorimotor zone.