Clinical analysis of human umbilical cord mesenchymal stem cell allotransplantation in patients with premature ovarian insufficiency

Objective Premature ovarian insufficiency (POI) is a refractory disease that seriously affects female fertility. Growing body of evidence has indicated mesenchymal stem cells (MSCs) as promising resources in regenerative medicine. In this study, we treated POI patients with umbilical cord‐derived MS...

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Bibliographic Details
Published in:Cell proliferation 2020-12, Vol.53 (12), p.e12938-n/a
Main Authors: Yan, Long, Wu, Yixuan, Li, Li, Wu, Jun, Zhao, Feiyan, Gao, Zheng, Liu, Wenjing, Li, Tianda, Fan, Yong, Hao, Jie, Liu, Jianqiao, Wang, Hongmei
Format: Article
Language:English
Subjects:
antral follicle
Apoptosis - physiology
Babies
Cancer therapies
Cell therapy
Clinical trials
Complications
Disease
dominant follicle
Ethics
Female
Fertility
Follicles
follow‐up
Good Manufacturing Practice
Hematology
Hormone replacement therapy
Hospitals
Humans
In vitro fertilization
Infertility
Injection
Kinases
mature follicle
Mesenchymal Stem Cell Transplantation - methods
Mesenchymal stem cells
Mesenchymal Stem Cells - cytology
Original
Original Manuscripts
Ovarian cancer
Ovary - cytology
Patients
Pregnancy
premature ovarian insufficiency
Primary Ovarian Insufficiency - therapy
Regenerative medicine
Reproductive status
Side effects
stem cell therapy
Stem cells
Substance abuse treatment
Surgeons
Transplantation
Ultrasonic imaging
Ultrasound
Umbilical cord
Umbilical Cord - cytology
umbilical cord mesenchymal stem cell
Vagina
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Summary:Objective Premature ovarian insufficiency (POI) is a refractory disease that seriously affects female fertility. Growing body of evidence has indicated mesenchymal stem cells (MSCs) as promising resources in regenerative medicine. In this study, we treated POI patients with umbilical cord‐derived MSCs (UCMSCs) and then investigated the restoration of ovarian function and clinical outcomes through follow‐ups. Materials and methods Sixty‐one patients diagnosed with POI participated in this study. UCMSCs were isolated and cultured according to GMP standards, and then transplanted to the patients’ ovary by orthotopic injection under the guidance of vaginal ultrasound. We monitored side effects, vital signs and changes in clinical and collected haematological and imaging parameters during the follow‐ups. Results All patients showed normal clinical behaviour without serious side effects or complications relevant to the treatment. Transplantation of UCMSCs rescued the ovarian function of POI patients, as indicated by increased follicular development and improved egg collection. POI patients who experienced shorter amenorrhoea durations (
ISSN:0960-7722
1365-2184
DOI:10.1111/cpr.12938