Prostate cancer measurements on serial MRI during active surveillance: it's time to be PRECISE

• Published in: British journal of radiology 2020-12, Vol.93 (1116), p.20200819-20200819
• Main Authors: Giganti, Francesco, Stavrinides, Vasilis, Stabile, Armando, Osinibi, Elizabeth, Orczyk, Clement, Radtke, Jan Philipp, Freeman, Alex, Haider, Aiman, Punwani, Shonit, Allen, Clare, Emberton, Mark, Kirkham, Alex, Moore, Caroline M
• Format: Article
• Language: English
• Subjects: Aged; Disease Progression; Humans; Male; Middle Aged; Multiparametric Magnetic Resonance Imaging; Neoplasm Staging; Prostatic Neoplasms - diagnostic imaging; Prostatic Neoplasms - pathology; Retrospective Studies; Tumor Burden; Watchful Waiting
• ISSN: 0007-1285; 1748-880X
• DOI: 10.1259/bjr.20200819

The PRECISE criteria for reporting multiparametric MRI in patients on active surveillance (AS) for prostate cancer (PCa) score the likelihood of clinically significant change over time using a 1-5 scale, where 4 or 5 indicates radiological progression. According to the PRECISE recommendations, the index lesion size can be reported using different definitions of volume (planimetry or ellipsoid formula) or by measuring one or two diameters. We compared different measurements using planimetry as the reference standard and stratified changes according to the PRECISE scores. We retrospectively analysed 196 patients on AS with PCa confirmed by targeted biopsy who had two MR scans (baseline and follow-up). Lesions were measured on weighted imaging ( WI) according to all definitions. A PRECISE score was assessed for each patient. The ellipsoid formula exhibited the highest correlation with planimetry at baseline (ρ = 0.97) and follow-up (ρ = 0.98) imaging, compared to the biaxial measurement and single maximum diameter. There was a significant difference ( < 0.001) in the yearly percentage volume change between radiological regression/stability (PRECISE 2-3) and progression (PRECISE 4-5) for planimetry (39.64%) and for the ellipsoid formula (46.78%). The ellipsoid formula could be used to monitor tumour growth during AS. Evidence of a significant yearly percentage volume change between radiological regression/stability (PRECISE 2-3) and progression (PRECISE 4-5) has been also observed. The ellipsoid formula is a reasonable surrogate for planimetry in capturing tumour volume changes on WI in patients on imaging-led AS. This is also associated with radiological changes using the PRECISE recommendations.