Prevalence, clinical characteristics, and outcomes of pediatric COVID-19: A systematic review and meta-analysis

•COVID-19 pediatric data from major world-wide epicenters is severely lacking as compared to the adult population.•Pediatric cases of COVID-19 tend to have a mild course and an overall favorable prognosis.•Clinical, laboratory, and radiological features are largely inconsistent and solely not predic...

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Bibliographic Details
Published in:Journal of clinical virology 2021-02, Vol.135, p.104715-104715, Article 104715
Main Authors: Badal, Sujan, Thapa Bajgain, Kalpana, Badal, Sujeena, Thapa, Rama, Bajgain, Bishnu B., Santana, Maria Jose
Format: Article
Language:English
Subjects:
Child
Clinical characteristics
COVID-19
COVID-19 - epidemiology
COVID-19 - pathology
COVID-19 - virology
Humans
Meta-analysis
Outcomes
Pandemics
Pediatric
Prevalence
SARS-CoV-2 - pathogenicity
Systematic review
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Summary:•COVID-19 pediatric data from major world-wide epicenters is severely lacking as compared to the adult population.•Pediatric cases of COVID-19 tend to have a mild course and an overall favorable prognosis.•Clinical, laboratory, and radiological features are largely inconsistent and solely not predictive of the disease diagnosis.•This study may provide important insights into the characterization and management of COVID-19 in the pediatric population. The novel coronavirus pandemic is an ongoing challenge faced by the public and health care systems around the globe. Majority of information and evidence gathered so far regarding COVID-19 has been derived from data and studies in adult populations. Crucial information regarding the characterization, clinical symptomatology, sequelae, and overall outcomes in the pediatric population is lacking. As such, we aimed to conduct a comprehensive meta-analysis and systematic review to collect and analyze current evidence about COVID-19 in the pediatric population. A systematic search and review of scientific literatures was conducted following the PRISMA guidelines using PubMed, Embase, Scopus, Medline, and Google Scholar databases. All relevant studies until June 16, 2020 were included. Studies were reviewed for methodological quality, and random-effects model was used to conduct the primary meta-analysis. I2 value and Egger’s test was used to estimate heterogeneity and publication bias respectively. We reviewed 20 eligible studies that included 1810 pediatric patient population (
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2020.104715