Use of simple scoring systems for a public health approach in the management of non‐alcoholic fatty liver disease patients

Background and Aim Advanced fibrosis is the most important predictor of liver‐related mortality in non‐alcoholic fatty liver disease (NAFLD). The aim of this study was to compare the diagnostic performance of noninvasive scoring systems in identifying advanced fibrosis in a Malaysian NAFLD cohort an...

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Bibliographic Details
Published in:JGH open 2020-12, Vol.4 (6), p.1155-1161
Main Authors: Zain, Shamsul Mohd, Tan, Hwa‐Li, Mohamed, Zahurin, Chan, Wah‐Kheong, Mahadeva, Sanjiv, Basu, Roma Choudhury, Mohamed, Rosmawati
Format: Article
Language:English
Subjects:
Accuracy
advanced fibrosis
Age
Biochemistry
Biopsy
Blood platelets
Body mass index
Cholesterol
Confidence intervals
Diabetes
fatty liver
FIB‐4
Hemoglobin
Hepatitis
Lipoproteins
Liver diseases
Mortality
non‐alcoholic fatty liver disease
Original
Public health
scoring system
Triglycerides
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Summary:Background and Aim Advanced fibrosis is the most important predictor of liver‐related mortality in non‐alcoholic fatty liver disease (NAFLD). The aim of this study was to compare the diagnostic performance of noninvasive scoring systems in identifying advanced fibrosis in a Malaysian NAFLD cohort and propose a simplified strategy for the management of NAFLD in a primary care setting. Methods We enrolled and reviewed 122 biopsy‐proven NAFLD patients. Advanced fibrosis was defined as fibrosis stages 3–4. Noninvasive assessments included aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio, AST‐to‐platelet ratio index (APRI), AST/ALT ratio, diabetes (BARD) score, fibrosis‐4 (FIB‐4) score, and NAFLD fibrosis score. Results FIB‐4 score had the highest area under the receiver operating characteristic curve (AUROC) and negative predictive value (NPV) of 0.86 and 94.3%, respectively, for the diagnosis of advanced fibrosis. FIB‐4 score 
ISSN:2397-9070
2397-9070
DOI:10.1002/jgh3.12414