French Pharmacovigilance Public System and COVID-19 Pandemic

The current COVID-19 pandemic is an exceptional health situation including for drug use. As there was no known effective drug for COVID-19 at the beginning of the pandemic, different candidates were proposed. In this short article, we present the French public pharmacovigilance activities during thi...

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Bibliographic Details
Published in:Drug safety 2021-04, Vol.44 (4), p.405-408
Main Authors: Grandvuillemin, Aurélie, Drici, Milou-Daniel, Jonville-Bera, Annie Pierre, Micallef, Joelle, Montastruc, Jean Louis
Format: Article
Language:English
Subjects:
Case reports
Clinical trials
Cognitive science
Coronaviruses
Councils
COVID-19
Current Opinion
Disease transmission
Drug Safety and Pharmacovigilance
Drugs
Emergency response
Medical personnel
Medicine
Medicine & Public Health
Middle East respiratory syndrome
Neuroscience
Pandemics
Pharmacology
Pharmacology/Toxicology
Pharmacovigilance
Public health
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Summary:The current COVID-19 pandemic is an exceptional health situation including for drug use. As there was no known effective drug for COVID-19 at the beginning of the pandemic, different candidates were proposed. In this short article, we present the French public pharmacovigilance activities during this health crisis. Although COVID-19 is a confounding factor per se, owing to its potential for multi-organ damage including the heart and kidney, the quality of the transmitted data in adverse drug reaction reports, the timeliness of feedback from clinicians, and the real-time pharmacological and medical analysis by the French network of the regional pharmacovigilance centers made it possible to swiftly identify relevant safety signals. The French National Agency of Medicine was thus able to validate the data and convey their findings very early. This decentralized organization based on medical and pharmacological evaluation of case reports has proven to be efficient and responsive in this unique and challenging healthcare emergency.
ISSN:0114-5916
1179-1942
DOI:10.1007/s40264-020-01034-y