STOML2 potentiates metastasis of hepatocellular carcinoma by promoting PINK1-mediated mitophagy and regulates sensitivity to lenvatinib

Background Dysregulation of both mitochondrial biogenesis and mitophagy is critical to sustain oncogenic signaling pathways. However, the mechanism of mitophagy in promoting hepatocellular carcinoma (HCC) progression remains poorly understood. In this study, we investigated the clinical significance...

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Bibliographic Details
Published in:Journal of hematology and oncology 2021-01, Vol.14 (1), p.16-18, Article 16
Main Authors: Zheng, Yahui, Huang, Chong, Lu, Lu, Yu, Kangkang, Zhao, Jing, Chen, Mingquan, Liu, Lu, Sun, Qingfeng, Lin, Zhifei, Zheng, Jianming, Chen, Jinhong, Zhang, Jubo
Format: Article
Language:English
Subjects:
Analysis
Angiogenesis
Animals
Antibodies
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Apoptosis - drug effects
Autophagy
Biosynthesis
Blood Proteins - analysis
Blood Proteins - metabolism
Cancer Research
Cancer therapies
Carcinoma, Hepatocellular - drug therapy
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Cell Line, Tumor
Cell migration
Cellular stress response
Confocal microscopy
Development and progression
DNA microarrays
Flow cytometry
Gene expression
Genes
Hematology
Hepatectomy
Hepatocellular carcinoma
Hepatocellular carcinoma (HCC)
Hepatoma
Hydroxychloroquine
Hypoxia
Hypoxia-inducible factor 1a
Immunoprecipitation
Kinases
Lenvatinib
Liver cancer
Liver Neoplasms - drug therapy
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Mass spectrometry
Medical prognosis
Medicine
Medicine & Public Health
Membrane proteins
Membrane Proteins - analysis
Membrane Proteins - metabolism
Metastases
Metastasis
Mice
Mice, Inbred BALB C
Mice, Nude
Mitochondria
Mitophagy
Mitophagy - drug effects
Neoplasm Invasiveness - pathology
Oncology
Parkin protein
Phagocytosis
Phenylurea Compounds - pharmacology
Phenylurea Compounds - therapeutic use
Protein Kinases - analysis
Protein Kinases - metabolism
Proteins
PTEN-induced putative kinase
PTEN-induced putative kinase 1 (PINK1)
Quinolines - pharmacology
Quinolines - therapeutic use
Scientific imaging
Statistical analysis
Stomatin-like protein 2 (STOML2)
Survival analysis
Transcription
Transmission electron microscopy
Tumors
Western blotting
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