Validating impact of pretreatment tumor growth rate on outcome of early‐stage lung cancer treated with stereotactic body radiation therapy

• Published in: Thoracic cancer 2021-01, Vol.12 (2), p.201-209
• Main Authors: Atallah, Soha, Le, Lisa W., Bezjak, Andrea, MacRae, Robert, Hope, Andrew J., Pantarotto, Jason
• Format: Article
• Language: English
• Subjects: Biopsy; Cancer therapies; Failure; Gender; Growth rate; Lung cancer; Medical prognosis; Original; predictive model; Radiation therapy; SBRT; Tumors
• ISSN: 1759-7706; 1759-7714
• DOI: 10.1111/1759-7714.13744

Background To assess correlation of pretreatment specific growth rate (SGR) value of 0.43 × 10‐2 with overall and failure‐free survival of patients with early‐stage non‐small cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT). Methods A retrospective chart review of 160 patients with pathologically confirmed stage I NSCLC treated with SBRT between June 2010 and December 2012 in a large, tertiary cancer institute was undertaken. Both diagnostic and archived planning CT were uploaded to the treatment planning system to determine tumor volume at diagnosis (GTV1) and planning time (GTV2). The time (t) between both CTs was recorded. SGR was calculated using GTV1, GTV2, and t. The median SGR (0.43 × 10‐2) from our previous data was used to group patients into low and high SGR cohorts. Log‐rank test was used to compare overall (OS) and failure‐free survivals (FFS) of SGR groups. Results The median time interval between diagnostic and planning CT scans was 87 days. The median OS was 38 and 66 months for high and low SGR cohorts, respectively (P = 0.03). The median FFS was 27 and 55 months for high and low SGR cohorts, respectively (P = 0.005). High SGR (P