Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning

•Considers methodological comparability of translational research in fear conditioning in rodents and humans.•Equips researchers with practical and methodological considerations across species to foster translational behavioural neuroscience.•Aid designing of future experiments that employ more comp...

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Bibliographic Details
Published in:Neuroscience and biobehavioral reviews 2019-12, Vol.107, p.329-345
Main Authors: Haaker, Jan, Maren, Stephen, Andreatta, Marta, Merz, Christian J., Richter, Jan, Richter, S. Helene, Meir Drexler, Shira, Lange, Maren D., Jüngling, Kay, Nees, Frauke, Seidenbecher, Thomas, Fullana, Miquel A., Wotjak, Carsten T., Lonsdorf, Tina B.
Format: Article
Language:English
Subjects:
Associative learning
Conditioning, Classical - physiology
Extinction, Psychological - physiology
Fear - physiology
Fear conditioning
Fear extinction
FPS
Heat-rate
Human
Humans
Individual differences
Meta-research
Methods
Neurosciences
Paradigm
Reflex, Startle - physiology
Rodent
SCR
Startle
Translation
Translational Research, Biomedical - methods
Treezing
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Summary:•Considers methodological comparability of translational research in fear conditioning in rodents and humans.•Equips researchers with practical and methodological considerations across species to foster translational behavioural neuroscience.•Aid designing of future experiments that employ more comparable processes in human participants and laboratory rodents in fear conditioning protocols.•Originates from discussions about fear conditioning protocols used in rodents and humans. Translational neuroscience bridges insights from specific mechanisms in rodents to complex functions in humans and is key to advance our general understanding of central nervous function. A prime example of translational research is the study of cross-species mechanisms that underlie responding to learned threats, by employing Pavlovian fear conditioning protocols in rodents and humans. Hitherto, evidence for (and critique of) these cross-species comparisons in fear conditioning research was based on theoretical viewpoints. Here, we provide a perspective to substantiate these theoretical concepts with empirical considerations of cross-species methodology. This meta-research perspective is expected to foster cross-species comparability and reproducibility to ultimately facilitate successful transfer of results from basic science into clinical applications.
ISSN:0149-7634
1873-7528
1873-7528
DOI:10.1016/j.neubiorev.2019.09.020