SARS-CoV-2-related chilblains

A healthy 16-year-old girl presented with a 2-week history of painful red-violaceous papules to her left third toe, right fifth toe and right index finger (Figure 1). She had no history of exposure to cold or damp and no systemic symptoms, but she lived with an asymptomatic front-line health care wo...

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Bibliographic Details
Published in:Canadian Medical Association journal (CMAJ) 2020-07, Vol.192 (28), p.E804-E804
Main Authors: Ladha, Malika A, Dupuis, Elaine C
Format: Article
Language:English
Subjects:
Administration, Topical
Adolescent
Adrenal Cortex Hormones
Antibodies
Anticardiolipin antibodies
Anticoagulants
Betacoronavirus - pathogenicity
Blood tests
Chilblains - pathology
Chilblains - virology
Coronavirus Infections - immunology
Coronavirus Infections - pathology
Coronavirus Infections - virology
Coronaviruses
COVID-19
Cryoglobulins
Disease transmission
Enzyme-Linked Immunosorbent Assay
Female
Fingers - blood supply
Fingers - virology
Health aspects
Humans
Laboratories
Medical diagnosis
Pandemics
Patient Education as Topic
Patients
Pneumonia, Viral - immunology
Pneumonia, Viral - pathology
Pneumonia, Viral - virology
Practice
Quarantine
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Toes - blood supply
Toes - virology
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Summary:A healthy 16-year-old girl presented with a 2-week history of painful red-violaceous papules to her left third toe, right fifth toe and right index finger (Figure 1). She had no history of exposure to cold or damp and no systemic symptoms, but she lived with an asymptomatic front-line health care worker. We diagnosed chilblains and investigated for systemic causes. Our investigation for secondary chilblains included a complete blood count, liver studies, and determination of the levels of creatinine, antinuclear antibody, extractable nuclear antigen, double-stranded DNA, anticardiolipin antibody, lupus anticoagulant, anti-?2-glycoprotein, complement, coagulation, D-dimer, cryoglobulins, cryofibringens and cold agglutinins, all of which gave results that were negative or within normal limits. As chilblains is often unrecognized, its incidence remains unknown. It more commonly affects women, and idiopathic chilblains is more common in children, whereas secondary chilblains usually presents in mid-adulthood.
ISSN:0820-3946
1488-2329
DOI:10.1503/cmaj.201348