Elevated monocyte distribution width in COVID-19 patients: The contribution of the novel sepsis indicator

• Published in: Clinica chimica acta 2020-10, Vol.509, p.22-24
• Main Authors: Ognibene, Agostino, Lorubbio, Maria, Magliocca, Pasqualino, Tripodo, Emanuela, Vaggelli, Guendalina, Iannelli, Giovanni, Feri, Marco, Scala, Raffaele, Tartaglia, Alessandro Polcini, Galano, Angelo, Pancrazzi, Alessandro, Tacconi, Danilo
• Format: Article
• Language: English
• Subjects: Adult; Aged; Betacoronavirus - isolation & purification; Cell Size; Clinical Laboratory Techniques - methods; Coronavirus Infections - blood; Coronavirus Infections - diagnosis; COVID-19; Female; Humans; Male; Middle Aged; Monocyte distribution width; Monocytes - metabolism; Monocytes - pathology; Pandemics; Pneumonia, Viral - blood; Pneumonia, Viral - diagnosis; SARS-CoV-2; Sepsis - blood; Sepsis - diagnosis
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2020.06.002

•Laboratory diagnostic parameters in symptomatic Covid19 disease patients.•Monocyte distribution width and monocyte modification in infection disease and sepsis.•SARS COV2 infection, prognosis in severe respiratory failure with multiple organ failure, clinical and laboratory finding. Interesting results regarding the contribution of MDW (Monocyte Distribution Width) in the Infectious Disease Unit have been reported. An observational study is ongoing at San Donato Hospital with the aim to evaluate the contribution of MDW in the diagnostic pathway in adult patients entering in the ED setting and tested for SARS-CoV-2. COVID-19 symptomatic and paucisymptomatic patients presenting to ED (Emergency Department), have been enrolled consecutively. Whole blood venous samples have been collected on K2 EDTA for MDW determination, at the same time a nasopharyngeal swab for SARS-CoV-2 RNA detection have been collected. One hundred six patients were negative for SARS-CoV-2 with MDW mean value of 20.3 ± 3.3, while forty-one were positive for SARS-CoV-2 with higher MDW mean value of 27.3 ± 4.9 (P