Diabetic Kidney Disease Benefits from Intensive Low-Protein Diet: Updated Systematic Review and Meta-analysis

A dietary protein intake (DPI) of between 0.6 and 0.8 g protein per kilogram body weight per day (g/kg/day) is frequently recommended for adults with moderate-to-advanced chronic kidney disease (CKD). However, evidence on whether patients with diabetic kidney disease (DKD) actually benefit from a DP...

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Bibliographic Details
Published in:Diabetes therapy 2021-01, Vol.12 (1), p.21-36
Main Authors: Li, Qiuling, Wen, Feng, Wang, Yanhui, Li, Sheng, Lin, Shaochun, Qi, Chunfang, Chen, Zujiao, Qiu, Xueqian, Zhang, Yifan, Zhang, Shaogui, Tao, Yiming, Feng, Zhonglin, Li, Zhilian, Li, Ruizhao, Ye, Zhiming, Liang, Xinling, Liu, Shuangxin, Xie, Jianteng, Wang, Wenjian
Format: Article
Language:English
Subjects:
Cardiology
Chronic kidney failure
Diabetes
Diabetic nephropathies
Diabetic nephropathy
Diet
Diet therapy
Drug therapy
Endocrinology
Health aspects
Internal Medicine
Kidney diseases
Low-protein diet
Medicine
Medicine & Public Health
Meta-analysis
Patient outcomes
Proteins
Review
Systematic review
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Summary:A dietary protein intake (DPI) of between 0.6 and 0.8 g protein per kilogram body weight per day (g/kg/day) is frequently recommended for adults with moderate-to-advanced chronic kidney disease (CKD). However, evidence on whether patients with diabetic kidney disease (DKD) actually benefit from a DPI of ≤ 0.8 g/kg/day and from a low-protein diet (LPD) at CKD stages 1–3 has not been consistent. We systematically searched MEDLINE, EMBASE, Cochrane Library, Web of Knowledge, as well as the bibliographies of articles identified in the search, for eligible randomized controlled trials that had investigated the effects of LPD (prescribed DPI
ISSN:1869-6953
1869-6961
DOI:10.1007/s13300-020-00952-5