Correlation of Technical and Adjunctive Factors with Quantitative Tumor Reduction in Children Undergoing Selective Ophthalmic Artery Infusion Chemotherapy for Retinoblastoma

Selective ophthalmic artery infusion chemotherapy has improved ocular outcomes in children with retinoblastoma. Our aim was to correlate quantitative tumor reduction and dichotomous therapeutic response with technical and adjunctive factors during selective ophthalmic artery infusion chemotherapy fo...

Full description

Saved in:
Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2021-02, Vol.42 (2), p.354-361
Main Authors: Abruzzo, T, Abraham, K, Karani, K B, Geller, J I, Vadivelu, S, Racadio, J M, Zhang, B, Correa, Z M
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Alkylating - administration & dosage
Child
Child, Preschool
Cohort Studies
Female
Fluoroscopy
Humans
Infant
Infusions, Intra-Arterial - methods
Interventional
Male
Melphalan - administration & dosage
Ophthalmic Artery
Pediatrics
Retinal Neoplasms - drug therapy
Retinoblastoma - drug therapy
Retrospective Studies
Treatment Outcome
Vasodilator Agents - administration & dosage
Verapamil - administration & dosage
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Selective ophthalmic artery infusion chemotherapy has improved ocular outcomes in children with retinoblastoma. Our aim was to correlate quantitative tumor reduction and dichotomous therapeutic response with technical and adjunctive factors during selective ophthalmic artery infusion chemotherapy for retinoblastoma. An understanding of such factors may improve therapeutic efficacy. All patients with retinoblastoma treated by selective ophthalmic artery infusion chemotherapy at a single center during a 9-year period were reviewed. Only first-cycle treatments for previously untreated eyes were studied. Adjunctive factors (intra-arterial verapamil, intranasal oxymetazoline external carotid balloon occlusion) and technical factors (chemotherapy infusion time, fluoroscopy time) were documented by medical record review. Quantitative tumor reduction was determined by blinded comparison of retinal imaging acquired during examination under anesthesia before and 3-4 weeks after treatment. The dichotomous therapeutic response was classified according to quantitative tumor reduction as satisfactory (≥ 50%) or poor (
ISSN:0195-6108
1936-959X
DOI:10.3174/ajnr.A6905