Prognostic Factors After Surgical Treatment of Liver Metastases from Breast Cancer - 19 Years of Experience

• Published in: In vivo (Athens) 2021-01, Vol.35 (1), p.417-422
• Main Authors: ProchÁzkovÁ, KristÝna, PivovarČÍkovÁ, KristÝna, RouŠarovÁ, Milena, VodiČka, Josef, HoŠek, Petr, TŘeŠkovÁ, Inka, Hes, OndŘej, KuČera, Radek, TopolČan, OndŘej, TŘeŠka, Vladislav
• Format: Article
• Language: English
• ISSN: 0258-851X; 1791-7549
• DOI: 10.21873/INVIVO.12273

The aim of this study was to determine the importance of surgical treatment, utility of hormone receptor status and selected biomarkers in the prognosis of patients with liver metastases from breast cancer (BCLM). Thirty female underwent surgery for BCLM between 1/2000 and 1/2019. The type of surgery (resection/radiofrequency ablation) had no impact on overall survival (OS) - (p=0.894). Having more than one BCLM (p=0.003), expression of human epidermal receptor 2 in metastases (p=0.034), as well as an elevated presurgical level of carbohydrate antigen 19-9 (p=0.017) and postsurgical thymidine kinase (p=0.034) were negative prognostics factor for recurrence-free survival. The factors affecting OS included the number of liver procedures (p=0.021), the degree of proliferative activity (p=0.008) and elevated postsurgical carcinoembryonic antigen level (p=0.038). The type of surgery had no impact on OS. Markers and hormonal status of liver metastases are important factors affecting prognosis.