The clinical utility of proton magnetic resonance spectroscopy in traumatic brain injury: recommendations from the ENIGMA MRS working group

Proton ( 1 H) magnetic resonance spectroscopy provides a non-invasive and quantitative measure of brain metabolites. Traumatic brain injury impacts cerebral metabolism and a number of research groups have successfully used this technique as a biomarker of injury and/or outcome in both pediatric and...

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Bibliographic Details
Published in:Brain imaging and behavior 2021-04, Vol.15 (2), p.504-525
Main Authors: Bartnik-Olson, Brenda L, Alger, Jeffry R, Babikian, Talin, Harris, Ashley D, Holshouser, Barbara, Kirov, Ivan I, Maudsley, Andrew A, Thompson, Paul M, Dennis, Emily L, Tate, David F, Wilde, Elisabeth A, Lin, Alexander
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Biomedical and Life Sciences
Biomedicine
Brain
Brain - diagnostic imaging
Brain Injuries, Traumatic - diagnostic imaging
Brain research
Child
Data acquisition
Head injuries
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Metabolites
Neuroimaging
Neuropsychology
Neuroradiology
Neurosciences
Pediatrics
Populations
Proton magnetic resonance
Proton Magnetic Resonance Spectroscopy
Psychiatry
Si: Enigma Tbi
Sodium
Spectrum analysis
Traumatic brain injury
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Summary:Proton ( 1 H) magnetic resonance spectroscopy provides a non-invasive and quantitative measure of brain metabolites. Traumatic brain injury impacts cerebral metabolism and a number of research groups have successfully used this technique as a biomarker of injury and/or outcome in both pediatric and adult TBI populations. However, this technique is underutilized, with studies being performed primarily at centers with access to MR research support. In this paper we present a technical introduction to the acquisition and analysis of in vivo 1 H magnetic resonance spectroscopy and review 1 H magnetic resonance spectroscopy findings in different injury populations. In addition, we propose a basic 1 H magnetic resonance spectroscopy data acquisition scheme ( Supplemental Information ) that can be added to any imaging protocol, regardless of clinical magnetic resonance platform. We outline a number of considerations for study design as a way of encouraging the use of 1 H magnetic resonance spectroscopy in the study of traumatic brain injury, as well as recommendations to improve data harmonization across groups already using this technique.
ISSN:1931-7557
1931-7565
DOI:10.1007/s11682-020-00330-6