Childhood Neurotoxicity and Brain Resilience to Adverse Events during Adulthood

Objective This study used childhood cancer survivors as a novel model to study whether children who experience central nervous system (CNS) injury are at higher risk for neurocognitive impairment associated with subsequent late onset chronic health conditions (CHCs). Methods Adult survivors of child...

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Bibliographic Details
Published in:Annals of neurology 2021-03, Vol.89 (3), p.534-545
Main Authors: Williams, AnnaLynn M., Cheung, Yin Ting, Hyun, Geehong, Liu, Wei, Ness, Kirsten K., Ehrhardt, Matthew J., Mulrooney, Daniel A., Bhakta, Nickhill, Banerjee, Pia, Brinkman, Tara M., Green, Daniel M., Chemaitilly, Wassim, Huang, I‐Chan, Srivastava, Deokumar, Hudson, Melissa M., Robison, Leslie L., Krull, Kevin R.
Format: Article
Language:English
Subjects:
Adult
Adverse events
Antimetabolites, Antineoplastic - therapeutic use
Brain
Cancer
Cancer Survivors
Cardiovascular Diseases - epidemiology
Central nervous system
Childhood
Children
Chronic Disease
Chronic illnesses
Cognition
Cognitive ability
Cognitive Dysfunction - epidemiology
Confidence intervals
Cranial Irradiation - statistics & numerical data
Endocrine System Diseases - epidemiology
Executive function
Humans
Impairment
Injections, Spinal
Logistic Models
Mental Status and Dementia Tests
Methotrexate
Methotrexate - therapeutic use
Nervous System Diseases - epidemiology
Neurocognitive Disorders - epidemiology
Neurosurgery
Neurosurgical Procedures - statistics & numerical data
Neurotoxicity
Neurotoxicity Syndromes
Odds Ratio
Quality
Radiation
Radiation Injuries
Respiratory Tract Diseases - epidemiology
Statistical analysis
Survival
Terminology
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Summary:Objective This study used childhood cancer survivors as a novel model to study whether children who experience central nervous system (CNS) injury are at higher risk for neurocognitive impairment associated with subsequent late onset chronic health conditions (CHCs). Methods Adult survivors of childhood cancer (n = 2,859, ≥10 years from diagnosis, ≥18 years old) completed a comprehensive neurocognitive battery and clinical examination. Neurocognitive impairment was defined as age‐adjusted z score 
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.25981