Molecularly Imprinted Polymer‐Based Smart Prodrug Delivery System for Specific Targeting, Prolonged Retention, and Tumor Microenvironment‐Triggered Release

Prodrug and drug delivery systems are two effective strategies for improving the selectivity of chemotherapeutics. Molecularly imprinted polymers (MIPs) have emerged as promising carriers in targeted drug delivery for cancer treatment, but they have not yet been integrated with the prodrug strategy....

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2021-02, Vol.60 (5), p.2663-2667
Main Authors: Gu, Zikuan, Dong, Yueru, Xu, Shuxin, Wang, Lisheng, Liu, Zhen
Format: Article
Language:English
Subjects:
Bioconversion
cancer
Communication
Communications
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Humans
Imprinted polymers
Liver
molecular imprinting
Molecularly Imprinted Polymers - chemistry
Nanoparticles
Polymers
Prodrugs - chemistry
Retention
Retention time
Selectivity
System effectiveness
Tumor Microenvironment
Tumors
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Summary:Prodrug and drug delivery systems are two effective strategies for improving the selectivity of chemotherapeutics. Molecularly imprinted polymers (MIPs) have emerged as promising carriers in targeted drug delivery for cancer treatment, but they have not yet been integrated with the prodrug strategy. Reported here is an MIP‐based smart prodrug delivery system for specific targeting, prolonged retention time, and tumor microenvironment‐triggered release. 5′‐Deoxy‐5‐fluorocytidine (DFCR) and sialic acid (SA) were used as a prodrug and a marker for tumor targeting, respectively. Their co‐imprinted nanoparticles were prepared as a smart carrier. Prodrug‐loaded MIP specifically and sustainably accumulated at the tumor site and then gradually released. Unlike conventional prodrug designs, which often require in‐liver bioconversion, this MIP‐based prodrug delivery is liver‐independent but tumor‐dependent. Thus, this study opens new access to the development of smart prodrug delivery nanoplatforms. A molecularly imprinted polymer (MIP) based smart prodrug delivery nanoplatform was demonstrated with the ability to specifically target tumor sites with prolonged retention time and gradual tumor microenvironmental pH‐triggered release. The MIP‐based prodrug delivery is liver‐independent but tumor‐dependent, which not only greatly enhances tumor specificity but also expands the scope of applicable prodrugs.
ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.202012956