Unilateral Isolated Primary Cutaneous Amyloidosis of the External Auditory Canal

Isolated primary cutaneous amyloidosis (PCA) of the external ear is extremely rare. We describe the case of a 65-year-old woman presenting with itching within the left external auditory canal (EAC). Otoscopy revealed a 3 mm whitish lesion involving the cartilaginous portion of the left EAC. The lesi...

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Bibliographic Details
Published in:Journal of International Advanced Otology 2020-12, Vol.16 (3), p.467-469
Main Authors: Magliulo, Giuseppe, de Vincentiis, Ludovica, Pace, Annalisa, Visconti, Irene Claudia, Foche, Rancesco Le, Riminucci, Mara, Corsi, Alessandro
Format: Article
Language:English
Subjects:
Amyloidosis
Case Report
Chronic illnesses
Cloning
Conflicts of interest
Females
Immunoglobulins
Molecular weight
Pathogenesis
Proteins
Systemic diseases
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Summary:Isolated primary cutaneous amyloidosis (PCA) of the external ear is extremely rare. We describe the case of a 65-year-old woman presenting with itching within the left external auditory canal (EAC). Otoscopy revealed a 3 mm whitish lesion involving the cartilaginous portion of the left EAC. The lesion was excised. Histological and immunohistochemical features were consistent with keratinic amyloidosis. A clinical workup was negative for systemic amyloidosis. As far as we know, only nine cases of PCA exclusively involving the EAC have been reported. The frequent occurrence of itching in these patients and the keratinic nature of the amyloid support the role of chronic stimulation/irritation in the pathogenesis of isolated amyloidosis the EAC.
ISSN:1308-7649
2148-3817
DOI:10.5152/iao.2020.7570