Antiretroviral Therapy Anchor-based Trends in Body Mass Index Following Treatment Initiation Among Military Personnel with HIV

ABSTRACT Introduction Weight gain and obesity in people living with HIV have been associated with increased risk for non-AIDS-related comorbidities, and integrase strand transfer inhibitor (INSTI)-based regimens may lead to comparatively more weight gain than other regimens. We evaluated body mass i...

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Published in:Military medicine 2021-02, Vol.186 (3-4), p.279-285
Main Authors: Kline, Maj David A, Daniels, Colton, Xu, Xiaohe, Sunil, Thankam, Ganesan, Anuradha, Agan, Brian K, Colombo, Rhonda E, Kronmann, Karl C, Blaylock, Jason M, Okulicz, Jason F, Markelz, A Elizabeth
Format: Article
Language:English
Subjects:
Adult
African Americans
Antiretroviral drugs
Armed forces
Body Mass Index
Brief Report
Drug therapy
Female
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - epidemiology
Human immunodeficiency virus
Humans
Male
Military Personnel
Reverse Transcriptase Inhibitors - therapeutic use
Viral Load
Young Adult
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Summary:ABSTRACT Introduction Weight gain and obesity in people living with HIV have been associated with increased risk for non-AIDS-related comorbidities, and integrase strand transfer inhibitor (INSTI)-based regimens may lead to comparatively more weight gain than other regimens. We evaluated body mass index (BMI) following antiretroviral therapy (ART) initiation among participants in the U.S. Military HIV Natural History Study (NHS). Materials and Methods NHS participants with available baseline weight and height data initiating ART from 2006 to 2017 were considered for analysis. Antiretroviral therapy was categorized by anchor class to include INSTIs, non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs). Linear growth-curve modeling was used to predict BMI changes from ART initiation through 2 years of follow-up in participants stratified by baseline BMI (
ISSN:0026-4075
1930-613X
DOI:10.1093/milmed/usaa416