Prenatal environmental exposures and associations with teen births

• Published in: Journal of exposure science & environmental epidemiology 2021-03, Vol.31 (2), p.197-210
• Main Authors: DeVille, Nicole V., Khalili, Roxana, Levy, Jonathan I., Korrick, Susan A., Vieira, Verónica M.
• Format: Article
• Language: English
• Subjects: Adolescent; Adolescents; Adult; Biomarkers; Birth; Births; Child; Children; Confidence intervals; DDE; Dichlorodiphenyl Dichloroethylene - analysis; Environmental aspects; Environmental Exposure - adverse effects; Environmental Pollutants - adverse effects; Environmental Pollutants - analysis; Epidemiology; Exposure; Female; Girls; Health aspects; Hexachlorobenzene; Humans; Impulsive behavior; Infant; Lead; Massachusetts - epidemiology; Maternal Exposure - adverse effects; Medicine; Medicine & Public Health; Mercury; Mercury (metal); Nitrous oxide; PCB; Pediatric research; Polychlorinated biphenyls; Polychlorinated Biphenyls - adverse effects; Polychlorinated Biphenyls - analysis; Pregnancy; Prenatal experience; Prenatal exposure; Prenatal Exposure Delayed Effects - chemically induced; Prenatal Exposure Delayed Effects - epidemiology; Prenatal influences; Psychological aspects; Risk factors; Risk management; Risk taking; Risk-taking (Psychology); Sensitivity analysis; Sexual behavior; Statistics; Teenage pregnancy; Teenagers
• ISSN: 1559-0631; 1559-064X
• DOI: 10.1038/s41370-020-00262-9

Background Children’s prenatal exposure to multiple environmental chemicals may contribute to subsequent deficits in impulse control, predisposing them to risk-taking. Objective Our goal was to investigate associations between prenatal exposure mixtures and risk of teen birth, a manifestation of high-risk sexual activity, among 5865 girls (1st generation) born in southeast Massachusetts from 1992–1998. Methods Exposures included prenatal modeled polychlorinated biphenyls (PCBs), ρ,ρ′-dichlorodiphenyl dichloroethylene (DDE), hexachlorobenzene (HCB), lead (Pb), and mercury (Hg). We fit adjusted generalized additive models with multivariable smooths of exposure mixtures, 1st generation infant’s birth year, and maternal age at 1st generation birth. Predicted odds ratios (ORs) for teen birth were mapped as a function of joint exposures. We also conducted sensitivity analyses among 1st generation girls with measured exposure biomarkers ( n  = 371). Results The highest teen birth risk was associated with a mixture of high prenatal HCB, Hg, Pb, and PCB, but low DDE exposure, with similar associations in sensitivity analyses. The highest OR predicted for girls born in 1995 to mothers of median age (26 years) was at the 95 th percentile of the HCB and PCB exposure distributions (OR = 3.09; 95% confidence interval: 0.29, 32.4). Additionally, girls born earlier in the study period or to teen mothers were at increased risk of teen birth. Significance Prenatal environmental chemical exposures and sociodemographic characteristics may interact to substantially increase risk of teen births.