Cognitive Implications of Deep Gray Matter Iron in Multiple Sclerosis

• Published in: American journal of neuroradiology : AJNR 2017-05, Vol.38 (5), p.942-948
• Main Authors: Fujiwara, E, Kmech, J A, Cobzas, D, Sun, H, Seres, P, Blevins, G, Wilman, A H
• Format: Article
• Language: English
• Subjects: Accumulation; Adult; Adult Brain; Atrophy; Cognition; Cognition & reasoning; Cognition Disorders - etiology; Cognitive ability; Female; Globus pallidus; Gray Matter - diagnostic imaging; Gray Matter - pathology; Humans; Image processing; Image segmentation; In vivo methods and tests; Iron; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Mapping; Measurement methods; Memory; Middle Aged; Multiple sclerosis; Multiple Sclerosis - complications; Multiple Sclerosis - diagnostic imaging; Multiple Sclerosis - pathology; Patients; Putamen; Substantia grisea; Thalamus
• ISSN: 0195-6108; 1936-959X
• DOI: 10.3174/ajnr.A5109

Deep gray matter iron accumulation is increasingly recognized in association with multiple sclerosis and can be measured in vivo with MR imaging. The cognitive implications of this pathology are not well-understood, especially vis-à-vis deep gray matter atrophy. Our aim was to investigate the relationships between cognition and deep gray matter iron in MS by using 2 MR imaging-based iron-susceptibility measures. Forty patients with multiple sclerosis (relapsing-remitting, = 16; progressive, = 24) and 27 healthy controls were imaged at 4.7T by using the transverse relaxation rate and quantitative susceptibility mapping. The transverse relaxation rate and quantitative susceptibility mapping values and volumes (atrophy) of the caudate, putamen, globus pallidus, and thalamus were determined by multiatlas segmentation. Cognition was assessed with the Brief Repeatable Battery of Neuropsychological Tests. Relationships between cognition and deep gray matter iron were examined by hierarchic regressions. Compared with controls, patients showed reduced memory ( < .001) and processing speed ( = .02) and smaller putamen ( < .001), globus pallidus ( = .002), and thalamic volumes ( < .001). Quantitative susceptibility mapping values were increased in patients compared with controls in the putamen ( = .003) and globus pallidus ( = .003). In patients only, thalamus ( < .001) and putamen ( = .04) volumes were related to cognitive performance. After we controlled for volume effects, quantitative susceptibility mapping values in the globus pallidus ( = .03; trend for transverse relaxation rate, = .10) were still related to cognition. Quantitative susceptibility mapping was more sensitive compared with the transverse relaxation rate in detecting deep gray matter iron accumulation in the current multiple sclerosis cohort. Atrophy and iron accumulation in deep gray matter both have negative but separable relationships to cognition in multiple sclerosis.