Genetic Variation in the Vascular Endothelial Growth Factor (VEGFA ) Gene at rs13207351 Is Associated with Overall Survival of Patients with Head and Neck Cancer

Head and neck cancer (HNC) is a significantly heterogeneous disease and includes malignancies arising from different anatomical sites, such as nasopharyngeal cancer (NPC) and laryngeal cancer (LC). In the current study, polymorphisms located in angiogenesis- and apoptosis-related genes ( , , and ) w...

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Published in:Cancers 2021-03, Vol.13 (5), p.1163
Main Authors: Dimitrakopoulos, Foteinos-Ioannis, Koliou, Georgia-Angeliki, Kotoula, Vassiliki, Papadopoulou, Kyriaki, Markou, Konstantinos, Vlachtsis, Konstantinos, Angouridakis, Nikolaos, Karasmanis, Ilias, Nikolaou, Angelos, Psyrri, Amanda, Visvikis, Anastasios, Kosmidis, Paris, Fountzilas, George, Koutras, Angelos
Format: Article
Language:English
Subjects:
Alleles
Angiogenesis
Apoptosis
Deoxyribonucleic acid
DNA
DNA repair
Genetic diversity
Head & neck cancer
Histology
Infections
Laryngeal cancer
Larynx
Medical prognosis
Patients
Signal transduction
Surgery
Survival
Tumors
Vascular endothelial growth factor
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Summary:Head and neck cancer (HNC) is a significantly heterogeneous disease and includes malignancies arising from different anatomical sites, such as nasopharyngeal cancer (NPC) and laryngeal cancer (LC). In the current study, polymorphisms located in angiogenesis- and apoptosis-related genes ( , , and ) were evaluated regarding their clinical significance in HNC patients. In total, 333 HNC patients were enrolled in this study and 34 variants located on the aforementioned genes were genotyped via Sanger sequencing. LC patients, homozygous A for rs13207351, had shorter overall survival (OS) as opposed to homozygous G (Hazard ratio (HR) = 2.06, Wald's 0.017) upon adjustment for age, disease stage, and surgery. Following the dominant model, LC patients carrying the A allele had a marginally significantly higher risk for death (HR = 1.72, = 0.059). NPC patients heterozygous (CT) for rs2234768 had a marginal but significantly higher risk of death compared to those with homozygosity for the T allele (HR = 2.22, = 0.056). In conclusion, rs13207351 ( ) and rs2234768 ( ) polymorphisms seem to have prognostic significance in HNC, with rs13207351 showing the most promise in this subgroup of LC patients.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13051163