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Hypovitaminosis D and the endocrine phenotype of COVID-19
Background Vitamin D and its deficiency have recently been suspected to be involved in increased susceptibility and negative outcomes of COVID-19. This assumption was based on the well known immunomodulatory actions of vitamin D and on the consistent finding of low levels of 25 hydroxyvitamin D (25O...
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| Published in: | Endocrine 2021-04, Vol.72 (1), p.1-11 |
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| Language: | English |
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| container_title | Endocrine |
| container_volume | 72 |
| creator | Giustina, Andrea |
| description | Background
Vitamin D and its deficiency have recently been suspected to be involved in increased susceptibility and negative outcomes of COVID-19. This assumption was based on the well known immunomodulatory actions of vitamin D and on the consistent finding of low levels of 25 hydroxyvitamin D (25OHD) in hospitalized patients with COVID-19. Moreover, several studies reported a correlation between 25OHD levels and different clinical outcomes of the disease.
Aim
Aim of the current review was to approach the topic of vitamin D and COVID-19 from a different perspective summarizing the data which led to the evidence of the existence of an endocrine phenotype of COVID-19.
Conclusions
This review analyzed in the light of the current knowledge the possibility that several endocrine manifestations of COVID-19 could be holistically interpreted in the context of an inadequate vitamin D status. |
| doi_str_mv | 10.1007/s12020-021-02671-8 |
| format | article |
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Vitamin D and its deficiency have recently been suspected to be involved in increased susceptibility and negative outcomes of COVID-19. This assumption was based on the well known immunomodulatory actions of vitamin D and on the consistent finding of low levels of 25 hydroxyvitamin D (25OHD) in hospitalized patients with COVID-19. Moreover, several studies reported a correlation between 25OHD levels and different clinical outcomes of the disease.
Aim
Aim of the current review was to approach the topic of vitamin D and COVID-19 from a different perspective summarizing the data which led to the evidence of the existence of an endocrine phenotype of COVID-19.
Conclusions
This review analyzed in the light of the current knowledge the possibility that several endocrine manifestations of COVID-19 could be holistically interpreted in the context of an inadequate vitamin D status.</description><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-021-02671-8</identifier><identifier>PMID: 33738708</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>25-Hydroxyvitamin D ; Coronaviruses ; COVID-19 ; Diabetes ; Endocrine Reports from the COVID-19 Frontline ; Endocrinology ; Humanities and Social Sciences ; Humans ; Immunomodulation ; Internal Medicine ; Medicine ; Medicine & Public Health ; multidisciplinary ; Phenotype ; Phenotypes ; Review ; SARS-CoV-2 ; Science ; Vitamin D ; Vitamin D Deficiency - complications ; Vitamin deficiency ; Vitamins</subject><ispartof>Endocrine, 2021-04, Vol.72 (1), p.1-11</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-909de126e3282755b7ab22f4cdec0a4c4a15cd7a1fbbceb334bce882ef40e45a3</citedby><cites>FETCH-LOGICAL-c474t-909de126e3282755b7ab22f4cdec0a4c4a15cd7a1fbbceb334bce882ef40e45a3</cites><orcidid>0000-0001-6783-3398</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33738708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giustina, Andrea</creatorcontrib><title>Hypovitaminosis D and the endocrine phenotype of COVID-19</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description>Background
Vitamin D and its deficiency have recently been suspected to be involved in increased susceptibility and negative outcomes of COVID-19. This assumption was based on the well known immunomodulatory actions of vitamin D and on the consistent finding of low levels of 25 hydroxyvitamin D (25OHD) in hospitalized patients with COVID-19. Moreover, several studies reported a correlation between 25OHD levels and different clinical outcomes of the disease.
Aim
Aim of the current review was to approach the topic of vitamin D and COVID-19 from a different perspective summarizing the data which led to the evidence of the existence of an endocrine phenotype of COVID-19.
Conclusions
This review analyzed in the light of the current knowledge the possibility that several endocrine manifestations of COVID-19 could be holistically interpreted in the context of an inadequate vitamin D status.</description><subject>25-Hydroxyvitamin D</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Diabetes</subject><subject>Endocrine Reports from the COVID-19 Frontline</subject><subject>Endocrinology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immunomodulation</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>multidisciplinary</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Review</subject><subject>SARS-CoV-2</subject><subject>Science</subject><subject>Vitamin D</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin deficiency</subject><subject>Vitamins</subject><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kUtLAzEUhYMoPqp_wIUMuHEzevNqZjaC1FdBcKPiLmQyd-xIm4zJVOi_N1qtj4WBcAPnuye5OYTsUzimAOokUgYMcmA07aGiebFGtqmUZQ5JX09nLmUOUDxukZ0YnwEYS9wm2eJc8UJBsU3K60XnX9vezFrnYxuz88y4OusnmKGrvQ2tw6yboPP9osPMN9no9mF8ntNyl2w0Zhpx77MOyP3lxd3oOr-5vRqPzm5yK5To8xLKGikbImcFU1JWylSMNcLWaMEIKwyVtlaGNlVlseJcpFIUDBsBKKThA3K69O3m1Qxri64PZqq70M5MWGhvWv1bce1EP_lXrUrFeFoDcvRpEPzLHGOvZ220OJ0ah34eNZPABReSDxN6-Ad99vPg0niJSp9Ny1IViWJLygYfY8Bm9RgK-j0ZvUxGpwb9kYx-bzr4Ocaq5SuKBPAlEJPknjB83_2P7RtBMZjL</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Giustina, Andrea</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6783-3398</orcidid></search><sort><creationdate>20210401</creationdate><title>Hypovitaminosis D and the endocrine phenotype of COVID-19</title><author>Giustina, Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-909de126e3282755b7ab22f4cdec0a4c4a15cd7a1fbbceb334bce882ef40e45a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Diabetes</topic><topic>Endocrine Reports from the COVID-19 Frontline</topic><topic>Endocrinology</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Immunomodulation</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>multidisciplinary</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Review</topic><topic>SARS-CoV-2</topic><topic>Science</topic><topic>Vitamin D</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin deficiency</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giustina, Andrea</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giustina, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypovitaminosis D and the endocrine phenotype of COVID-19</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>72</volume><issue>1</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>Background
Vitamin D and its deficiency have recently been suspected to be involved in increased susceptibility and negative outcomes of COVID-19. This assumption was based on the well known immunomodulatory actions of vitamin D and on the consistent finding of low levels of 25 hydroxyvitamin D (25OHD) in hospitalized patients with COVID-19. Moreover, several studies reported a correlation between 25OHD levels and different clinical outcomes of the disease.
Aim
Aim of the current review was to approach the topic of vitamin D and COVID-19 from a different perspective summarizing the data which led to the evidence of the existence of an endocrine phenotype of COVID-19.
Conclusions
This review analyzed in the light of the current knowledge the possibility that several endocrine manifestations of COVID-19 could be holistically interpreted in the context of an inadequate vitamin D status.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>33738708</pmid><doi>10.1007/s12020-021-02671-8</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-6783-3398</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Endocrine, 2021-04, Vol.72 (1), p.1-11 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7972333 |
| source | Springer Link |
| subjects | 25-Hydroxyvitamin D Coronaviruses COVID-19 Diabetes Endocrine Reports from the COVID-19 Frontline Endocrinology Humanities and Social Sciences Humans Immunomodulation Internal Medicine Medicine Medicine & Public Health multidisciplinary Phenotype Phenotypes Review SARS-CoV-2 Science Vitamin D Vitamin D Deficiency - complications Vitamin deficiency Vitamins |
| title | Hypovitaminosis D and the endocrine phenotype of COVID-19 |
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