Oral Health and the Altered Colonic Mucosa-Associated Gut Microbiota

Background Systemic diseases have been associated with oral health and gut microbiota. We examined the association between oral health and the community composition and structure of the adherent colonic gut microbiota. Methods We obtained 197 snap-frozen colonic biopsies from 62 colonoscopy-confirme...

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Bibliographic Details
Published in:Digestive diseases and sciences 2021-09, Vol.66 (9), p.2981-2991
Main Authors: Xu, Anthony A., Hoffman, Kristi, Gurwara, Shawn, White, Donna L., Kanwal, Fasiha, El-Serag, Hashem B., Petrosino, Joseph F., Jiao, Li
Format: Article
Language:English
Subjects:
Analysis
Bacterial Load - methods
Biochemistry
Biological diversity
Biopsy - methods
Colon - microbiology
Colon - pathology
Colonoscopy
Correlation of Data
Female
Gastroenterology
Gastrointestinal Microbiome - genetics
Gastrointestinal Microbiome - immunology
Gum disease
Hepatology
Humans
Inflammation
Inflammation - immunology
Inflammation - microbiology
Life Style
Male
Mediation
Medicine
Medicine & Public Health
Microbiota
Microbiota (Symbiotic organisms)
Microbiota - genetics
Microbiota - immunology
Middle Aged
Oncology
Oral Health
Oral hygiene
Original Article
Periodontal Diseases - diagnosis
Periodontal Diseases - epidemiology
RNA
RNA, Ribosomal, 16S - isolation & purification
Sequence Analysis, DNA - methods
Tooth Loss - diagnosis
Tooth Loss - epidemiology
Transplant Surgery
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Summary:Background Systemic diseases have been associated with oral health and gut microbiota. We examined the association between oral health and the community composition and structure of the adherent colonic gut microbiota. Methods We obtained 197 snap-frozen colonic biopsies from 62 colonoscopy-confirmed polyp-free individuals. Microbial DNA was sequenced for the 16S rRNA V4 region using the Illumina MiSeq, and the sequences were assigned to the operational taxonomic unit based on SILVA. We used a questionnaire to ascertain tooth loss, gum disease, and lifestyle factors. We compared biodiversity and relative abundance of bacterial taxa based on the amount of tooth loss and the presence of gum disease. The multivariable negative binomial regression model for panel data was used to estimate the association between the bacterial count and oral health. False discovery rate-adjusted P value ( q value) 
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-020-06612-9