Stage–specific incidence trends of renal cancers in the East of England, 1999–2016

•Renal cancer incidence is increasing globally.•The contribution of early or late stage disease in unclear.•During 1999−2016 increasing incidence was chiefly driven by early stage disease.•For most of the study period advanced stage renal cancer was deceasing.•The findings are compatible with a rang...

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Bibliographic Details
Published in:Cancer epidemiology 2021-04, Vol.71 (Pt A), p.101883-101883, Article 101883
Main Authors: Herbert, Annie, Barclay, Matthew E., Koo, Minjoung M., Rous, Brian, Greenberg, David C., Abel, Gary, Lyratzopoulos, Georgios
Format: Article
Language:English
Subjects:
Adult
Age groups
Aged
Cancer
Classification
Databases, Factual
Datasets
Deprivation
Diagnosis
Disease
England - epidemiology
Epidemiology
Estimates
Female
Humans
Incidence
Kidney cancer
Kidney Neoplasms - epidemiology
Kidney Neoplasms - pathology
Kidneys
Male
Medical diagnosis
Middle Aged
Neoplasm Staging
Patients
Population
Registration
Renal
Sensitivity analysis
Stage
Trends
Tumors
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Summary:•Renal cancer incidence is increasing globally.•The contribution of early or late stage disease in unclear.•During 1999−2016 increasing incidence was chiefly driven by early stage disease.•For most of the study period advanced stage renal cancer was deceasing.•The findings are compatible with a range of interpretations. To determine stage-specific time-trends in renal cancer incidence. We used population-based East Anglia data 1999−2016 (population ∼2 million) on 5,456 primary renal cancer diagnoses, estimating stage-specific annual incidence using Poisson regression, allowing for changing time-trends, and adjusting for sex, age, and socioeconomic deprivation. Renal cancer incidence increased from 9.8–16.4 cases per 100,000 during 1999−2016. Incidence of Stage I, II, and III cases increased over time, most steeply for Stage I, with annual Incidence Rate Ratio [IRR] for Stage I of 1.09 (95 % CI 1.07–1.12) during 1999−2010; and 1.03 (1.00–1.05) during 2011−2016. In contrast, the annual incidence of Stage IV renal cancer decreased during most years, IRR of 0.99 (0.98–1.00) during 2003−2016. The findings are consistent with both earlier detection of symptomatic renal cancer and increasing identification of asymptomatic lesions. However, the decreasing incidence of late-stage disease suggests genuine shifts towards earlier diagnosis.
ISSN:1877-7821
1877-783X
DOI:10.1016/j.canep.2020.101883