Obesity-related multimorbidity and risk of cardiovascular disease in the middle-aged population in the United States

• Published in: Preventive medicine 2020-10, Vol.139, p.106225-106225, Article 106225
• Main Authors: Pollack, Lisa M., Wang, Mei, Leung, Man Yee Mallory, Colditz, Graham, Herrick, Cynthia, Chang, Su-Hsin
• Format: Article
• Language: English
• Subjects: Adult; Aged; Cardiovascular Diseases - epidemiology; Chronic Disease; Humans; Middle Aged; Multimorbidity; Nutrition Surveys; Obesity; Obesity - epidemiology; Prevalence; United States - epidemiology; Washington
• ISSN: 0091-7435; 1096-0260
• DOI: 10.1016/j.ypmed.2020.106225

To investigate the prevalence of obesity-related multimorbidity (co-occurrence of ≥2 obesity-related chronic diseases, ORCDs) and the risk of cardiovascular disease in the presence of multimorbidity in middle-aged adults in the United States. National Health and Nutrition Examination Survey data from 2007 to 2016 were used. Target ORCDs included hypertension (H), diabetes (D), coronary heart disease (C), and stroke (S). Age-standardized prevalence for obesity-related multimorbidity in its combination and permutation was calculated. Risk for cardiovascular disease (C or S) was estimated conditional on demographics, degree of obesity, and presence and duration of pre-existing ORCDs. Analyses were conducted at Washington University in 2019. The analytic sample included 14,243 individuals age 40–79 years, representing a population size of 110,003,550. Age-standardized prevalence for obesity-related multimorbidity was 12.3%. Hypertension was most commonly the first diagnosed ORCD for populations with 2–4 ORCDs, followed by diabetes for populations with 2–3 ORCDs. Compared with no pre-existing hypertension/diabetes/stroke, pre-existing hypertension in combination with diabetes/stroke significantly increased risk of coronary heart disease [H + S (multivariable-adjusted hazard ratio, aHR 27.6, 95% CI 10.9–70.2), D + H + S (aHR 20.3, 95% CI 7.9–52.2)]. Compared with no hypertension/diabetes/coronary heart disease, pre-existing hypertension in combination with diabetes/coronary heart disease significantly increased risk of stroke [C + D + H (aHR 32.6, 95% CI 12.2–87.1), C + H (aHR 25.4, 95% CI 12.1–53.6), D + H (aHR 5.3, 95% CI 2.6–10.8)]. Obesity-related multimorbidity is prevalent and highly associated with cardiovascular disease development. To reduce the detrimental health impact of multimorbidity, intervention strategies should target preventing increasing multimorbidity and detecting/managing diabetes and hypertension prior to the onset of cardiovascular disease. •The prevalence of obesity-related multimorbidity was 12% in the U.S. population age 40–79 years from 2007 to 2016.•Among the population with obesity-related multimorbidity, hypertension was most commonly the first diagnosed disease.•Risk of cardiovascular disease increased substantially with pre-existing multimorbidity, independent of degree of obesity.•Intervention strategies to reduce cardiovascular disease should include preventing increasing multimorbidity.