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Diet‐independent relevance of serum uric acid for blood pressure in a representative population sample

A direct relationship between serum uric acid and blood pressure (BP) has been reported, but the possible confounding impact of diet on this association is unclear. The authors performed a cross‐sectional analysis in the representative German Health Interview and Examination Survey for Adults (n=678...

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Published in:	The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2017-10, Vol.19 (10), p.1042-1050
Main Authors:	Krupp, Danika, Esche, Jonas, Mensink, Gert BM, Neuhauser, Hannelore K, Remer, Thomas
Format:	Article
Language:	English
Subjects:	Adolescent Adult Aged Blood Pressure - physiology Cross-Sectional Studies diet Diet - adverse effects Dose-Response Relationship, Drug Female Germany Germany - epidemiology Humans hypertension Hypertension - blood Hypertension - complications Hypertension - epidemiology Hypertension - physiopathology Hyperuricemia - complications Hyperuricemia - epidemiology Male Middle Aged Original Paper Prevalence Risk Factors Uric Acid Uric Acid - blood Young Adult
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container_title	The journal of clinical hypertension (Greenwich, Conn.)
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creator	Krupp, Danika Esche, Jonas Mensink, Gert BM Neuhauser, Hannelore K Remer, Thomas
description	A direct relationship between serum uric acid and blood pressure (BP) has been reported, but the possible confounding impact of diet on this association is unclear. The authors performed a cross‐sectional analysis in the representative German Health Interview and Examination Survey for Adults (n=6788, aged 18–79 years). In adjusted regression models considering dietary factors, each 1‐mg/dL higher uric acid value was associated with a 1.10‐mm Hg (P=.0002) and a 0.60‐mm Hg (P=.04) higher systolic BP among participants younger than 50 years and participants 50 years and older, respectively. For diastolic BP, uric acid was a significant predictor (β=0.71 mm Hg, P=.0001) among participants younger than 50 years and for participants 50 years and older without antihypertensive treatment. Adjusted odds ratios of hypertension for participants with hyperuricemia were broadly similar in younger (odds ratio, 1.71; P=.02) and older (odds ratio, 1.81; P=.0003) participants. Uric acid is a significant predictor of systolic BP and hypertension prevalence in the general adult population in Germany independently of several known dietary BP influences.
doi_str_mv	10.1111/jch.13046
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subjects	Adolescent Adult Aged Blood Pressure - physiology Cross-Sectional Studies diet Diet - adverse effects Dose-Response Relationship, Drug Female Germany Germany - epidemiology Humans hypertension Hypertension - blood Hypertension - complications Hypertension - epidemiology Hypertension - physiopathology Hyperuricemia - complications Hyperuricemia - epidemiology Male Middle Aged Original Paper Prevalence Risk Factors Uric Acid Uric Acid - blood Young Adult
title	Diet‐independent relevance of serum uric acid for blood pressure in a representative population sample
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