Lower Glomerular Filtration Rate Is Associated With Higher Systemic Vascular Resistance in Patients Without Prevalent Kidney Disease

• Published in: The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2014-10, Vol.16 (10), p.722-728
• Main Authors: Vääräniemi, Kati, Koskela, Jenni, Tahvanainen, Anna, Tikkakoski, Antti, Wilenius, Matias, Kähönen, Mika, Kööbi, Tiit, Niemelä, Onni, Mustonen, Jukka, Pörsti, Ilkka
• Format: Article
• Language: English
• Subjects: Adult; Cardiography, Impedance; Creatinine - blood; Cystatin C - blood; Essential Hypertension; Female; Finland; Glomerular Filtration Rate - physiology; Hemodynamics - physiology; Humans; Hypertension - diagnosis; Hypertension - physiopathology; Hypertension, Renal - diagnosis; Hypertension, Renal - physiopathology; Kidney Diseases - diagnosis; Kidney Diseases - physiopathology; Male; Middle Aged; Original Paper; Original Papers; Reference Values; Statistics as Topic; Vascular Resistance - physiology
• ISSN: 1524-6175; 1751-7176; 1751-7176
• DOI: 10.1111/jch.12405

The authors examined the association between estimated glomerular filtration rate (eGFR), calculated using the Chronic Kidney Disease Epidemiology Collaboration creatinine‐cystatin C equation, and hemodynamics in 556 normotensive or never‐treated hypertensive patients without kidney disease (mean age, 46 years). Hemodynamic variables were recorded using pulse wave analysis and whole‐body impedance cardiography. The mean eGFR was 98 mL/min/1.73 m2 (range, 64–145 mL/min/1.73 m2 and one third of the patients had values below 92, while none had proteinuria. In linear regression analyses adjusted for differences in age, weight:height ratio, low‐density lipoprotein cholesterol, and sex, significant associations were found between lower eGFR and higher systolic (P=.001) and diastolic blood pressure (P