The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms

Purpose Recent evidence supports a key role of gut microbiome in brain health. We conducted a pilot study to assess associations of gut microbiome with cancer-related fatigue and explore the associations with DNA methylation changes. Methods Self-reported Multidimensional Fatigue Inventory and stool...

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Bibliographic Details
Published in:Supportive care in cancer 2021-06, Vol.29 (6), p.3173-3182
Main Authors: Xiao, Canhua, Fedirko, Veronika, Beitler, Jonathan, Bai, Jinbing, Peng, Gang, Zhou, Chao, Gu, Jianlei, Zhao, Hongyu, Lin, I-Hsin, Chico, Cynthia E., Jeon, Sangchoon, Knobf, Tish M., Conneely, Karen N., Higgins, Kristin, Shin, Dong M., Saba, Nabil, Miller, Andrew, Bruner, Deborah
Format: Article
Language:English
Subjects:
Analysis
Cancer
Digestive system
DNA methylation
Epigenesis, Genetic - genetics
Epigenetic inheritance
Ethylenediaminetetraacetic acid
Fatigue
Fatigue - etiology
Fatigue - pathology
Fatty acids
Female
Gastrointestinal Microbiome - physiology
Humans
Inflammation
Male
Medicine
Medicine & Public Health
Methylation
Microbiota
Microbiota (Symbiotic organisms)
Middle Aged
Neoplasms - complications
Neoplasms - genetics
Nursing
Nursing Research
Oncology
Oncology, Experimental
Original Article
Pain Medicine
Pilot Projects
Radiation therapy
Radiotherapy
Rehabilitation Medicine
RNA
Synthesis
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Summary:Purpose Recent evidence supports a key role of gut microbiome in brain health. We conducted a pilot study to assess associations of gut microbiome with cancer-related fatigue and explore the associations with DNA methylation changes. Methods Self-reported Multidimensional Fatigue Inventory and stool samples were collected at pre-radiotherapy and one-month post-radiotherapy in patients with head and neck cancer. Gut microbiome data were obtained by sequencing the 16S ribosomal ribonucleic acid gene. DNA methylation changes in the blood were assessed using Illumina Methylation EPIC BeadChip. Results We observed significantly different gut microbiota patterns among patients with high vs. low fatigue across time. This pattern was characterized by low relative abundance in short-chain fatty acid–producing taxa (family Ruminococcaceae, genera Subdoligranulum and Faecalibacterium ; all p  
ISSN:0941-4355
1433-7339
DOI:10.1007/s00520-020-05820-3