The Impact of NOD2 Genetic Variants on the Gut Mycobiota in Crohn’s Disease Patients in Remission and in Individuals Without Gastrointestinal Inflammation

Abstract Background and Aims Historical and emerging data implicate fungi in Crohn’s disease [CD] pathogenesis. However, a causal link between mycobiota, dysregulated immunity, and any impact of NOD2 variants remains elusive. This study aims to evaluate associations between NOD2 variants and faecal...

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Bibliographic Details
Published in:Journal of Crohn's and colitis 2021-05, Vol.15 (5), p.800-812
Main Authors: Nelson, Andrew, Stewart, Christopher J, Kennedy, Nicholas A, Lodge, John K, Tremelling, Mark, Probert, Chris S, Parkes, Miles, Mansfield, John C, Smith, Darren L, Hold, Georgina L, Lees, Charlie W, Bridge, Simon H, Lamb, Christopher A
Format: Article
Language:English
Subjects:
Adult
Aged
Case-Control Studies
Crohn Disease - genetics
Feces - microbiology
Female
Gastrointestinal Microbiome - genetics
Genotype
Humans
Male
Middle Aged
Mutation
Mycoses - genetics
Mycoses - microbiology
Nod2 Signaling Adaptor Protein - genetics
Original
Remission Induction
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Summary:Abstract Background and Aims Historical and emerging data implicate fungi in Crohn’s disease [CD] pathogenesis. However, a causal link between mycobiota, dysregulated immunity, and any impact of NOD2 variants remains elusive. This study aims to evaluate associations between NOD2 variants and faecal mycobiota in CD patients and non-CD subjects. Methods Faecal samples were obtained from 34 CD patients [18 NOD2 mutant, 16 NOD2 wild-type] identified from the UK IBD Genetics Consortium. To avoid confounding influence of mucosal inflammation, CD patients were in clinical remission and had a faecal calprotectin 
ISSN:1873-9946
1876-4479
DOI:10.1093/ecco-jcc/jjaa220