In vivo oral insulin delivery via covalent organic frameworks

With diabetes being the 7th leading cause of death worldwide, overcoming issues limiting the oral administration of insulin is of global significance. The development of imine-linked-covalent organic framework (nCOF) nanoparticles for oral insulin delivery to overcome these delivery barriers is here...

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Published in:Chemical science (Cambridge) 2021-04, Vol.12 (17), p.6037-6047
Main Authors: Benyettou, Farah, Kaddour, Nawel, Prakasam, Thirumurugan, Das, Gobinda, Sharma, Sudhir Kumar, Thomas, Sneha Ann, Bekhti-Sari, Fadia, Whelan, Jamie, Alkhalifah, Mohammed A, Khair, Mostafa, Traboulsi, Hassan, Pasricha, Renu, Jagannathan, Ramesh, Mokhtari-Soulimane, Nassima, Gándara, Felipe, Trabolsi, Ali
Format: Article
Language:English
Subjects:
Biocompatibility
Chemistry
Hyperglycemia
Insulin
Nanoparticles
Nanosheets
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Summary:With diabetes being the 7th leading cause of death worldwide, overcoming issues limiting the oral administration of insulin is of global significance. The development of imine-linked-covalent organic framework (nCOF) nanoparticles for oral insulin delivery to overcome these delivery barriers is herein reported. A gastro-resistant nCOF was prepared from layered nanosheets with insulin loaded between the nanosheet layers. The insulin-loaded nCOF exhibited insulin protection in digestive fluids as well as glucose-responsive release, and this hyperglycemia-induced release was confirmed in diabetic rats without noticeable toxic effects. This is strong evidence that nCOF-based oral insulin delivery systems could replace traditional subcutaneous injections easing insulin therapy.
ISSN:2041-6520
2041-6539
DOI:10.1039/d0sc05328g