The remodel of the “central dogma”: a metabolomics interaction perspective

Background In 1957, Francis Crick drew a linear diagram on a blackboard. This diagram is often called the “central dogma.” Subsequently, the relationships between different steps of the “central dogma” have been shown to be considerably complex, mostly because of the emerging world of small molecule...

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Bibliographic Details
Published in:Metabolomics 2021-05, Vol.17 (5), p.48-48, Article 48
Main Authors: Costa dos Santos, Gilson, Renovato-Martins, Mariana, de Brito, Natália Mesquita
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Developmental Biology
Diet
Epigenetics
Gastrointestinal Microbiome
Heredity
Intestinal microflora
Life Sciences
Metabolites
Metabolomics
Microbiomes
Molecular Medicine
Phenotypes
Review
Review Article
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Summary:Background In 1957, Francis Crick drew a linear diagram on a blackboard. This diagram is often called the “central dogma.” Subsequently, the relationships between different steps of the “central dogma” have been shown to be considerably complex, mostly because of the emerging world of small molecules. It is noteworthy that metabolites can be generated from the diet through gut microbiome metabolism, serve as substrates for epigenetic modifications, destabilize DNA quadruplexes, and follow Lamarckian inheritance. Small molecules were once considered the missing link in the “central dogma”; however, recently they have acquired a central role, and their general perception as downstream products has become reductionist. Metabolomics is a large-scale analysis of metabolites, and this emerging field has been shown to be the closest omics associated with the phenotype and concomitantly, the basis for all omics. Aim of review Herein, we propose a broad updated perspective for the flux of information diagram centered in metabolomics, including the influence of other factors, such as epigenomics, diet, nutrition, and the gut- microbiome. Key scientific concepts of review Metabolites are the beginning and the end of the flux of information.
ISSN:1573-3882
1573-3890
DOI:10.1007/s11306-021-01800-8